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Hormonal correlations of premature ejaculation

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Abstract

Premature ejaculation is the most frequent male sexual dysfunction, significantly impairing quality of life of both the patient and the partner and affecting up to one-third of men of every age. In the last years, our knowledge about this topic has greatly increased, and studies on the causes and treatments related to ejaculatory disorders have shed a light on previously uncharted territory. Public interest on sexual dysfunctions has likewise increased in the general population: the time lapse between the first symptoms of sexual dysfunction and the seeking of medical advice has been significantly reduced, whereas demand for a treatment has markedly increased. A role of endocrine regulation has been established in all the aspects of male reproduction; however, the endocrine control of ejaculation is not fully understood. Sex steroid, pituitary, and thyroid hormones have all been advocated as potential candidates in the regulation of the ejaculatory process, but exact mechanisms are not clear yet and further studies are required in order to identify potential targets for treatment.

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  1. Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, “Sapienza” University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy

    Andrea Sansone, Francesco Romanelli & Andrea Lenzi

  2. Department of Systems Medicine, Tor Vergata University of Rome, Via Montpellier, 1, 00133, Rome, Italy

    Emmanuele A. Jannini

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  1. Andrea Sansone
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Sansone, A., Romanelli, F., Jannini, E.A. et al. Hormonal correlations of premature ejaculation. Endocrine 49, 333–338 (2015). https://doi.org/10.1007/s12020-014-0520-7

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