Endocrine

, Volume 44, Issue 2, pp 473–480

Vitamin D status and 5-year changes in urine albumin creatinine ratio and parathyroid hormone in a general population

  • Tea Skaaby
  • Lise Lotte Nystrup Husemoen
  • Charlotta Pisinger
  • Torben Jørgensen
  • Betina Heinsbæk Thuesen
  • Knud Rasmussen
  • Mogens Fenger
  • Peter Rossing
  • Allan Linneberg
Original Article

DOI: 10.1007/s12020-013-9887-0

Cite this article as:
Skaaby, T., Husemoen, L.L.N., Pisinger, C. et al. Endocrine (2013) 44: 473. doi:10.1007/s12020-013-9887-0

Abstract

Vitamin D is associated with cardiovascular disease and renal function but the mechanisms are as yet unexplained. Microalbuminuria is associated with a higher risk of kidney function loss, cardiovascular disease, and mortality. Parathyroid hormone is a predictor of cardiovascular mortality and negatively correlated with glomerular filtration rate. We investigated the association between vitamin D status and 5-year changes in urine albumin creatinine ratio (UACR) and parathyroid hormone (PTH). A random sample of 6,784 individuals aged 30−60 years from a general population participated in the Inter99 study in 1999–2001. Vitamin D (serum-25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography. UACR and PTH were measured at baseline and follow-up. Increased UACR was defined as UACR >4.0 mg/g reflecting the upper quartile at baseline. We included 4,330 individuals who participated at 5-year follow-up. In multivariable linear regression analysis, a 10-nmol/l higher baseline level of vitamin D was associated with a 5-year decrease in UACR by 0.92 % (95 % confidence interval, CI 0.13, 1.71). In multivariable logistic regression analysis, the odds ratio of developing increased UACR during follow-up was 0.96 (95 % CI 0.92, 0.98) per 10 nmol/l higher baseline vitamin D level. We found a significant inverse cross-sectional (p < 0.0001) but no prospective association (p = 0.6) between baseline vitamin D status and parathyroid hormone. We found low vitamin D status to be a predictor of long-term development of increased UACR. It remains to be proven whether vitamin D deficiency is a causal and reversible factor in the development of albuminuria.

Keywords

AlbuminuriaParathyroid hormoneProspectiveUrine albumin creatinine ratioVitamin D

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Tea Skaaby
    • 1
  • Lise Lotte Nystrup Husemoen
    • 1
  • Charlotta Pisinger
    • 1
  • Torben Jørgensen
    • 1
    • 2
    • 3
  • Betina Heinsbæk Thuesen
    • 1
  • Knud Rasmussen
    • 4
  • Mogens Fenger
    • 5
  • Peter Rossing
    • 6
    • 7
    • 8
  • Allan Linneberg
    • 1
  1. 1.Research Centre for Prevention and Health, Glostrup HospitalGlostrupDenmark
  2. 2.Faculty of Health Science, University of CopenhagenCopenhagenDenmark
  3. 3.Faculty of Medicine, Alborg UniversityAlborgDenmark
  4. 4.Department of MedicineRoskilde University HospitalRoskildeDenmark
  5. 5.Department of Clinical BiochemistryHvidovre HospitalHvidovreDenmark
  6. 6.Steno Diabetes CenterGentofteDenmark
  7. 7.University of CopenhagenCopenhagenDenmark
  8. 8.University of AarhusAarhusDenmark