Endocrine

, Volume 44, Issue 2, pp 403–410

Impact of incretin on early-phase insulin secretion and glucose excursion

  • Jie Shen
  • Zhi Chen
  • Chaofeng Chen
  • Xiao Zhu
  • Yajuan Han
Original Article

DOI: 10.1007/s12020-012-9867-9

Cite this article as:
Shen, J., Chen, Z., Chen, C. et al. Endocrine (2013) 44: 403. doi:10.1007/s12020-012-9867-9

Abstract

This study investigated the impact of incretin on early-phase insulin secretion and glucose excursion. The normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) groups included 16, 8, and 19 subjects, respectively. Subjects underwent continuous glucose monitoring for 3 days, followed by an oral glucose tolerance test. Plasma glucose, insulin, glucagon, total glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-l (GLP-1) levels were measured at 30-min increments for 2 h after glucose intake. Differences with P < 0.05 were considered statistically significant. The area under the curve (AUC) of total GIP (120-min GIP-AUC) of the T2DM group was significantly lower than those of the NGT and IGT groups. The 120-min GLP-1-AUC of the NGT group was significantly larger than those of the T2DM and IGT groups. The early-phase insulin secretion index (ΔI30/ΔG30) of the T2DM group was significantly lower than those of the NGT and IGT groups. Mean amplitudes of glycemic excursions (MAGEs) went in the order of NGT < IGT < T2DM (P < 0.01, IGT vs. NGT; P < 0.001, T2DM vs. IGT). The 120-min GIP-AUC was negatively correlated with MAGE (r = −0.464), but uncorrelated with ΔI30/ΔG30. The 120-min GLP-1-AUC was positively correlated with ΔI30/ΔG30 (r = 0.580), but negatively correlated with MAGE (r = −0.606). Incretin may ameliorate glucose excursions, and GLP-1 may exert them by promoting early-phase insulin secretion. No correlation was observed between GIP secretion and early-phase insulin secretion.

Keywords

Incretin Early-phase insulin secretion Glucose excursion Continuous Glucose monitoring Oral glucose tolerance test 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jie Shen
    • 1
  • Zhi Chen
    • 1
  • Chaofeng Chen
    • 1
  • Xiao Zhu
    • 1
  • Yajuan Han
    • 1
  1. 1.Department of EndocrinologyThe Third Affiliated Hospital of Southern Medical UniversityGuang ZhouPeople’s Republic of China

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