Endocrine

, Volume 44, Issue 2, pp 380–385

Metabolic fuel utilization and subclinical atherosclerosis in overweight/obese subjects

Authors

    • Clinical Nutrition Unit, Department of Medical and Surgical ScienceUniversity Magna Grecia, Catanzaro
  • Carmine Gazzaruso
    • Diabetes, Endocrine-Metabolic Diseases and Cardiovascular Prevention UnitClinical Institute “Beato Matteo”
    • Department of Internal MedicineI.R.C.C.S. Policlinico San Donato Milanese
  • Yvelise Ferro
    • Clinical Nutrition Unit, Department of Medical and Surgical ScienceUniversity Magna Grecia, Catanzaro
  • Valeria Migliaccio
    • Clinical Nutrition Unit, Department of Medical and Surgical ScienceUniversity Magna Grecia, Catanzaro
  • Stefania Rotundo
    • Clinical Nutrition Unit, Department of Medical and Surgical ScienceUniversity Magna Grecia, Catanzaro
  • Alberto Castagna
    • Clinical Nutrition Unit, Department of Medical and Surgical ScienceUniversity Magna Grecia, Catanzaro
  • Arturo Pujia
    • Clinical Nutrition Unit, Department of Medical and Surgical ScienceUniversity Magna Grecia, Catanzaro
Original Article

DOI: 10.1007/s12020-012-9845-2

Cite this article as:
Montalcini, T., Gazzaruso, C., Ferro, Y. et al. Endocrine (2013) 44: 380. doi:10.1007/s12020-012-9845-2

Abstract

The utilization of different macronutrients is relevant for the risk of obesity, diabetes, or the appearing of vascular complications. The Respiratory Quotient (RQ) is a parameter measuring the fuel utilizations; in fact, it can indicate the fat stores utilization or lipogenesis activation. Aim of this study was to investigate the link between the RQ and the subclinical carotid atherosclerosis presence in overweight/obese subjects. 132 subjects with body mass index at least 25, at conventional diet, underwent an Indirect Calorimetry for the measurement of the Resting Metabolic Rate as well as the RQ and an evaluation of carotid arteries with ultrasound. Biochemical analyses were also performed. The mean age was 48 ± 12 years. There was a positive relation between carotid intima-media thickness and RQ (p = 0.010), with the high value in the subgroup with high RQ (p = 0.045 vs. group with low RQ). The RQ, an index of fuel utilization, is positively associated to subclinical carotid atherosclerosis in overweight/obese individuals.

Keywords

Obesity Atherosclerosis Indirect calorimetry Respiratory Quotient

Abbreviations

RQ

Respiratory Quotient

CIMT

Carotid intima media thickness

RMR

Resting metabolic rate

WC

Waist circumference

BMI

Body mass index

SBP

Systolic blood pressure

DBP

Diastolic blood pressure

Copyright information

© Springer Science+Business Media New York 2012