Endocrine

, Volume 44, Issue 1, pp 114–118

Portal and systemic levels of visfatin in morbidly obese subjects undergoing bariatric surgery

  • Zohreh Karbaschian
  • Mohammad Javad Hosseinzadeh-Attar
  • Ladan Giahi
  • Atefeh Golpaie
  • Farzad Masoudkabir
  • Mohammad Talebpour
  • Farid Kosari
  • Nargess Karbaschian
  • Mostafa Hoseini
  • Maryam Mazaherioun
Original Article

DOI: 10.1007/s12020-012-9821-x

Cite this article as:
Karbaschian, Z., Hosseinzadeh-Attar, M.J., Giahi, L. et al. Endocrine (2013) 44: 114. doi:10.1007/s12020-012-9821-x

Abstract

The aim of the present study was to compare the levels of visfatin in portal and systemic circulations and to assess the possible relationship of visfatin with systemic inflammation and insulin resistance in morbidly obese patients undergoing bariatric surgery. A total of 46 morbidly obese patients (BMI = 45.3 ± 5.3 kg/m2) undergoing bariatric surgery were included in this study. Blood samplings were performed simultaneously from portal and systemic veins during surgery. Visfatin was measured in both portal and systemic venous samples. Besides, fasting serum levels of insulin, glucose, lipid profile, visfatin, and hs-CRP were determined in systemic venous blood samples. Insulin sensitivity was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Visfatin concentrations were significantly higher in portal vein than systemic veins (11.9 ± 12.1 vs. 5.1 ± 3.3 ng/ml, p < 0.0001). While systemic levels of visfatin were significantly correlated with circulating levels of hs-CRP (r = 0.527, p < 0.0001), there were no significant correlations between portal levels of visfatin with systemic levels of hs-CRP concentrations. Substantially higher levels of visfatin in portal vein than systemic veins provide evidence that visceral adipose tissue is the major secretory source of visfatin in humans. Our findings underscore that visceral adipose tissue is an active endocrine organ that is involved in the complex interrelationship between obesity and pathologic conditions.

Keywords

Obesity Nicotinamide phosphoribosyltransferase Visfatin Adipokines 

Abbreviations

CVD

Cardiovascular diseases

TNF-α

Tumor necrosis factor-α

IL-6

Interleukin-6

PBEF

Pre-B cell colony-enhancing factor-1

BMI

Body mass index

WC

Waist circumference

WHR

Waist-to-hip ratio

TC

Total cholesterol

TG

Triglyceride

LDL-C

Low-density lipoprotein cholesterol

HDL-C

High-density lipoprotein cholesterol

hs-CRP

High-sensitivity C-reactive protein

HOMA-IR

Homeostasis model assessment for insulin resistance

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Zohreh Karbaschian
    • 1
    • 2
  • Mohammad Javad Hosseinzadeh-Attar
    • 3
    • 4
  • Ladan Giahi
    • 5
  • Atefeh Golpaie
    • 3
    • 4
  • Farzad Masoudkabir
    • 6
    • 7
  • Mohammad Talebpour
    • 4
    • 8
  • Farid Kosari
    • 9
  • Nargess Karbaschian
    • 10
  • Mostafa Hoseini
    • 11
  • Maryam Mazaherioun
    • 1
  1. 1.Tehran University of Medical Sciences, International Campus, (TUMS, IC)TehranIran
  2. 2.Shahid Beheshti University of Medical Sciences, International Branch, (SBMU, IB)TehranIran
  3. 3.Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health ResearchTehran University of Medical SciencesTehranIran
  4. 4.Endocrine and Metabolism Research Center (EMRC), Obesity and Food Group SetTehran University of Medical SciencesTehranIran
  5. 5.Department of Nutrition, Faculty of Life ScienceUniversity of ViennaViennaAustria
  6. 6.Students’ Scientific Research Center (SSRC)Tehran University of Medical SciencesTehranIran
  7. 7.Department of Cardiology, Tehran Heart CenterTehran University of Medical SciencesTehranIran
  8. 8.Department of Surgery, Laparoscopic Surgical Ward, Sina HospitalTehran University of Medical SciencesTehranIran
  9. 9.Department of Pathology, Sina HospitalTehran University of Medical SciencesTehranIran
  10. 10.Department of NutritionIslamic Azad University, Science and Research BranchTehranIran
  11. 11.Epidemiology and Biostatistics Department, School of Public HealthTehran University of Medical SciencesTehranIran

Personalised recommendations