Original Article

Endocrine

, Volume 43, Issue 3, pp 603-610

First online:

Changes in ghrelin and asymmetrical dimethylarginine in obese Mexican adolescents after six-month lifestyle intervention

  • Fengyang HuangAffiliated withDepartment of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG)
  • , Blanca Estela del-Río-NavarroAffiliated withDepartment of Allergy, Hospital Infántil de México Federico Gómez (HIMFG) Email author 
  • , José Alfredo Pérez OntiverosAffiliated withDepartment of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG)
  • , Eliseo Ruiz-BedollaAffiliated withLaboratory Center, Hospital Infántil de México Federico Gómez (HIMFG)
  • , Efraín Navarro-OlivosAffiliated withDepartment of Environmental Health, Instituto Nacional de Salud Pública
  • , Santiago VillafañaAffiliated withSuperior School of Medicine, National Polytechnic Institute
  • , Guadalupe BravoAffiliated withDepartment of Pharmacobiology, Centro de Investigación de Estudio Avanzados del Instituto Politécnico Nacional
  • , Enrique HongAffiliated withDepartment of Pharmacobiology, Centro de Investigación de Estudio Avanzados del Instituto Politécnico Nacional

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Abstract

The aim of this study was to evaluate the effect of a six-month lifestyle intervention on ghrelin and asymmetrical dimethylarginine (ADMA) in obese Mexican adolescents. A total of 65 obese Mexican adolescents aged 10–16 years completed a six-month lifestyle intervention. Anthropometric and biochemical parameters were assessed at baseline and at six months. Twenty normal-weight adolescents were also evaluated at baseline. Insulin resistance (IR) was determined by the homeostasis model assessment of IR (HOMA-IR). Ghrelin and ADMA were determined by enzyme-linked immunosorbent assay. Obese adolescents presented significantly higher triglycerides, cholesterol, glucose, insulin, HOMA-IR, and ADMA levels, while ghrelin was significantly lower. The lifestyle intervention led to a significant improvement in HOMA-IR, ghrelin, and ADMA in the whole studied obese subjects. ADMA and ghrelin levels were associated with BMI and IR components. According to the value of HOMA-IR, the obese subjects were divided into subjects with or without IR, no difference in ghrelin and ADMA was observed in these two subgroups. After intervention, the obese with IR showed increased ghrelin and decreased ADMA, while the obese without IR only showed improvement in ghrelin. The multiple linear regression analysis revealed that the changes of systolic blood pressure were the only predictor for the changes of ghrelin in the obese with IR. Our study demonstrated the increase of ADMA and the decrease of ghrelin in obese adolescents. Lifestyle intervention improved insulin resistance, decreased ADMA, and increased ghrelin in obese subjects with IR although no significant weight loss was observed.

Keywords

Ghrelin Asymmetrical dimethylarginine Obese adolescents Lifestyle intervention