Original Article

Endocrine

, Volume 43, Issue 1, pp 161-169

A missense polymorphism (rs11466653, Met326Thr) of toll-like receptor 10 (TLR10) is associated with tumor size of papillary thyroid carcinoma in the Korean population

  • Su Kang KimAffiliated withKohwang Medical Research Institute, School of Medicine, Kyung Hee University
  • , Hae Jeong ParkAffiliated withKohwang Medical Research Institute, School of Medicine, Kyung Hee University
  • , Il Ki HongAffiliated withNuclear Medicine, School of Medicine, Kyung Hee University
  • , Joo-Ho ChungAffiliated withKohwang Medical Research Institute, School of Medicine, Kyung Hee University Email author 
  • , Young Gyu EunAffiliated withDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University Email author 

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Abstract

Toll-like receptors (TLRs) are important components of innate immune response. The aim of this study was to investigate whether TLR gene cluster (TLR10-TLR1-TLR6) polymorphisms are associated with the etiology of papillary thyroid carcinoma (PTC) and its clinicopathologic characteristics. We recruited 94 PTC patients and 325 control subjects. Genotypes for each SNP were determined by direct sequencing. SNPStats and SPSS 18.0 were used to evaluate odds ratios (ORs), 95 % confidence intervals (CIs), and P values. Multiple logistic regression analyzes of genetic data were performed. The missense SNP rs11466653 was associated with small tumor size (<1 cm) in PTC. The frequency of the rs11466653 T allele was higher in PTC patients with tumors <1 cm in size than in the control group (95.8 vs. 87.2 %; P = 0.021, OR = 0.30, 95 % CI = 0.11–0.83). The T allele of rs11466653 (T/C, Met326Thr) in TLR10 may be a risk factor for the development of tumors in PTC in the Korean population.

Keywords

Toll-like receptor Papillary thyroid carcinoma Single nucleotide polymorphism Tumor size Association study