Endocrine

, Volume 43, Issue 1, pp 108–111

Celiac disease in subjects with type 1 diabetes mellitus: a prevalence study in western Sicily (Italy)

  • Domenico Greco
  • Maria Pisciotta
  • Francesco Gambina
  • Filippo Maggio
Original Article

DOI: 10.1007/s12020-012-9718-8

Cite this article as:
Greco, D., Pisciotta, M., Gambina, F. et al. Endocrine (2013) 43: 108. doi:10.1007/s12020-012-9718-8

Abstract

The association between celiac disease and type 1 diabetes mellitus is well known. Up to now, celiac disease prevalence in children and adults with type 1 diabetes in Sicily has not been reported. The aim of this study was to assess the prevalence of celiac disease in patients with type 1 diabetes mellitus who come from a defined geographical area in western Sicily and to investigate the clinical features of these subjects. The records of 492 consecutive patients with type 1 diabetes mellitus referred in a period of 5 years were analyzed. During the period of the survey, out of 492 patients with type 1 diabetes, 22 (4.5 %) had a previous diagnosis of celiac disease. There were 14 females and 8 males; these patients showed a mean age of 13 years at diabetes onset. Diagnosis of celiac disease was often simultaneous or subsequent to that of diabetes. Autoimmune thyroiditis was coexisting in 8 patients (36 %). Our data confirm, in a Sicilian population, the not unusual association between celiac disease and type 1 diabetes, although prevalence rate is lower than in others Italian studies. Autoimmune thyroiditis is present with high prevalence in these patients. Celiac disease diagnosis often followed onset of type 1 diabetes, particularly in female subjects with a young age at diabetes onset; therefore, in these subjects, an active search for the presence of celiac disease is warranted for many years after appearance of diabetes.

Keywords

Type 1 diabetes mellitus Celiac disease Prevalence Autoimmune thyroiditis 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Domenico Greco
    • 1
    • 2
  • Maria Pisciotta
    • 1
  • Francesco Gambina
    • 1
  • Filippo Maggio
    • 1
  1. 1.Division of DiabetologyPaolo Borsellino HospitalMarsalaItaly
  2. 2.EriceItaly