Endocrine

, Volume 42, Issue 2, pp 307–320

Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population

Meta-Analysis

DOI: 10.1007/s12020-012-9643-x

Cite this article as:
Jing, C., Xueyao, H. & Linong, J. Endocrine (2012) 42: 307. doi:10.1007/s12020-012-9643-x

Abstract

The multiple small-scale association studies of candidate genes for type 2 diabetes mellitus in the Chinese Han population have shown inconsistent results. Here, we performed a meta-analysis to evaluate the contribution of five candidate genes to the pathogenesis of type 2 diabetes in the Chinese Han population. We searched for relevant published papers and used STATA v.11.0 to perform a meta-analysis on six single-nucleotide polymorphisms in five genes—ADIPOQ-rs2241766 (SNP45) and -rs1501299 (SNP276), ADRB3-rs4994 (Trp64Arg), CAPN10-rs3792267 (SNP43), ENPP1-rs1044498 (K121Q), and PPARGC1A-rs8192678 (Gly482Ser)—in the Chinese Han population under an additive genetic model. The pooled odds ratios (95% confidence intervals and P-values) were 0.71 (0.60–0.83; P < 0.001) for ADIPOQ-rs2241766, 0.79 (0.64–0.97; P = 0.027) for ADIPOQ-rs1501299, 1.27 (1.07–1.51; P = 0.006) for ADRB3-rs4994, 0.79 (0.57–1.10; P = 0.163) for CAPN10-rs3792267, 1.41 (1.13–1.76; P = 0.003) for ENPP1-rs1044498, and 1.54 (1.34–1.81; P < 0.001) for PPARGC1A-rs8192678. There was high heterogeneity for ADIPOQ-rs2241766, ADIPOQ-rs1501299, and CAPN10-rs3792267 (I2 = 74.9, 69.4, and 75.8%, respectively), but not for ADRB3-rs4994, ENPP1-rs1044498, and PPARGC1A-rs8192678 (I2 = 0.0, 43.4, and 23.3%, respectively). Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.

Keywords

Meta-analysisCandidate genesType 2 diabetesChineseHan

Abbreviations

T2DM

Type 2 diabetic mellitus

NGT

Normal glucose tolerance

GWAS

Genome wide association study

SNP

Single-nucleotide polymorphism

ADIPOQ

Adiponectin C1Q and collagen domain containing

ADRB3

Adrenergic-beta-3-receptor

ENPP1

Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1

PPARGC1A

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

CAPN10

Calpain 10

FTO

Fat mass and obesity

OR

Odds ratios

CNKI

China National Knowledge infrastructure

HWE

Hardy–Weinberg equilibrium

ADA

American Diabetes Association

WHO

World Health organization

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Endocrinology and MetabolismPeking University People’s HospitalBeijingPeople’s Republic of China