Endocrine

, Volume 42, Issue 3, pp 694–699

Nesfatin-1 and other hormone alterations in polycystic ovary syndrome

  • Rulin Deniz
  • Bilgin Gurates
  • Suleyman Aydin
  • Husnu Celik
  • İbrahim Sahin
  • Yakup Baykus
  • Zekiye Catak
  • Aziz Aksoy
  • Cihan Citil
  • Sami Gungor
Original Article

DOI: 10.1007/s12020-012-9638-7

Cite this article as:
Deniz, R., Gurates, B., Aydin, S. et al. Endocrine (2012) 42: 694. doi:10.1007/s12020-012-9638-7

Abstract

Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman–Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.

Keywords

PCOSNesfatin-1Ferriman–Gallwey scores

Abbreviations

17-Αhp

17 Alpha hydroxyprogesterone

AS

Androstenedione

BMI

Body mass index

CSF

Cerebrospinal fluid

CV

Coefficient of variance

DHEA-S

Dehydroepiandrosterone sulphate

DM

Diabetes mellitus

E2

Estradiol

EDTA

Ethylenediaminetetraacetic acid

FABP4

Fatty acid binding protein

FBG

Fasting blood glucose

FG

Ferriman–Gallwey

FSH

Follicle-stimulating hormone

FSI

Fasting serum insulin

HDL

High density lipoprotein

HOMA-IR

Homeostasis model of assessment-insulin resistance index

IGF-1

Insulin-like growth factor

IR

Insulin resistance

KIU

Kallikrein inactivation unit

LDL

Low density lipoprotein

LH

Luteinizing hormone

LMD

Last menstrual date

PCOS

Polycystic ovary syndrome

PRL

Prolactin

SHBG

Sex-hormone binding globulin

TSH

Thyroid-stimulating hormone

TT

Total testosterone

VLDL

Very low density lipoprotein

WHR

Waist-hip circumference ratio

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Rulin Deniz
    • 1
  • Bilgin Gurates
    • 1
  • Suleyman Aydin
    • 2
  • Husnu Celik
    • 1
  • İbrahim Sahin
    • 3
  • Yakup Baykus
    • 1
  • Zekiye Catak
    • 2
  • Aziz Aksoy
    • 4
  • Cihan Citil
    • 5
  • Sami Gungor
    • 1
  1. 1.Department of Obstetrics and GynecologyFirat University HospitalElazigTurkey
  2. 2.Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research GroupFirat University HospitalElazigTurkey
  3. 3.Department of Nutrition and DieteticsErzincan UniversityErzincanTurkey
  4. 4.Department of Nutrition and DieteticsBitlis Eren UniversityBitlisTurkey
  5. 5.Department of Biological ScienceFirat UniversityElazigTurkey