Endocrine

, Volume 38, Issue 2, pp 303–308

Haptoglobin phenotype in women with preeclampsia

  • Rami N. Sammour
  • Farid M. Nakhoul
  • Andrew P. Levy
  • Rachel Miller-Lotan
  • Nakhoul Nakhoul
  • Hoda R. Awad
  • Ron Gonen
  • Gonen Ohel
Original Article

DOI: 10.1007/s12020-010-9392-7

Cite this article as:
Sammour, R.N., Nakhoul, F.M., Levy, A.P. et al. Endocr (2010) 38: 303. doi:10.1007/s12020-010-9392-7

Abstract

In pre-eclampsia, poor placentation causes both oxidative and endoplasmic reticulum stress of the placenta. The anti-oxidative protein Haptoglobin has three phenotypes: 1-1, 1-2, and 2-2. Haptoglobin 1-1 is a more potent antioxidant. Our objective was to determine whether haptoglobin 1-1 was less common in women with preeclampsia which is a disease with an oxidatives-stress component, compared to the healthy population. Haptoglobin phenotype was compared in 240 healthy and 120 preeclamptic gravida in a case–control study. Statistical analysis was performed using Chi square test. The prevalence of haptoglobin 1-1 was 13% among healthy women and 6% among preeclamptic women (P = 0.049). Secondary analysis was also performed. The prevalence of haptoglobin 1-1 is higher in healthy compared to preeclamptic subjects, a finding compatible with a protective role. Haptoglobin 1-1 might have a protective role in preeclampsia. Further work is needed with more Hp 1-1 subjects before we can conclude on the possible use of Haptoglobin phenotype to assess the risk of preeclampsia.

Keywords

Haptoglobin Phenotype Preeclampsia Oxidative stress 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Rami N. Sammour
    • 1
  • Farid M. Nakhoul
    • 2
    • 3
    • 4
  • Andrew P. Levy
    • 3
    • 4
  • Rachel Miller-Lotan
    • 3
  • Nakhoul Nakhoul
    • 3
  • Hoda R. Awad
    • 3
  • Ron Gonen
    • 1
    • 4
  • Gonen Ohel
    • 1
    • 4
  1. 1.Department of Obstetrics and GynecologyBnai-Zion Medical CenterHaifaIsrael
  2. 2.Ambulatory Nephrology Unit, Rambam Health-Care CampusTechnion-Faculty of MedicineHaifaIsrael
  3. 3.Department of Vascular Medicine, Rappaport Faculty of MedicineTechnion Israel Institute of TechnologyHaifaIsrael
  4. 4.Rappaport Faculty of MedicineTechnion Israel Institute of TechnologyHaifaIsrael

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