Endocrine

, Volume 38, Issue 1, pp 24–28

Liver failure due to antithyroid drugs: report of a case and literature review

  • Sarantis Livadas
  • Xenofon Xyrafis
  • Frangiskos Economou
  • Georgios Boutzios
  • Maria Christou
  • Aristea Zerva
  • Athanasios Karachalios
  • Helen Palioura
  • Sotiria Palimeri
  • Evanthia Diamanti-Kandarakis
Case Report and Review

DOI: 10.1007/s12020-010-9348-y

Cite this article as:
Livadas, S., Xyrafis, X., Economou, F. et al. Endocr (2010) 38: 24. doi:10.1007/s12020-010-9348-y

Abstract

Hyperthyroidism is a common endocrine disorder affecting 2% of females and 0.5% of males worldwide and antithyroid drugs constitute the first line of treatment in the majority of cases. These agents may cause severe adverse effects and among them liver failure, although rare, is a potential lethal one. This case illustrates the sudden and abrupt deterioration of hepatic function due to antithyroid drug administration. This case along with a concise literature review is presented aiming to increase the awareness of endocrinologists of possible fatal complications from the everyday use of common agents such as antithyroid drugs.

Keywords

Liver failureHyperthyroidismPropylthiouracilMethimazoleTransaminasesThionamides

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Sarantis Livadas
    • 1
  • Xenofon Xyrafis
    • 1
  • Frangiskos Economou
    • 1
  • Georgios Boutzios
    • 1
  • Maria Christou
    • 1
  • Aristea Zerva
    • 1
  • Athanasios Karachalios
    • 1
  • Helen Palioura
    • 1
  • Sotiria Palimeri
    • 1
  • Evanthia Diamanti-Kandarakis
    • 1
    • 2
  1. 1.Endocrine Section, First Department of Internal Medicine, Laiko General Hospital, Medical SchoolUniversity of AthensAthensGreece
  2. 2.University of Athens Medical SchoolAthensGreece