Endocrine

, Volume 37, Issue 2, pp 312–321

Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation

  • Marcie R. Kritzik
  • Cory U. Lago
  • Ayse G. Kayali
  • Sandrine Arnaud-Dabernat
  • Guoxun Liu
  • You-Qing Zhang
  • Hong Hua
  • Howard S. Fox
  • Nora E. Sarvetnick
Original Article

DOI: 10.1007/s12020-009-9297-5

Cite this article as:
Kritzik, M.R., Lago, C.U., Kayali, A.G. et al. Endocr (2010) 37: 312. doi:10.1007/s12020-009-9297-5
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Abstract

The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.

Keywords

PancreasIntestineRegenerationSDF1CXCR4

Abbreviations

NOD

Non-obese diabetic

SCID

Severe combined immunodeficiency

FACS

Fluorescence activated cell sorting

LCA

Leukocyte common antigen

SDF1a

Stromal-derived-factor-1 alpha

CXCR4

Chemokine (C-X-C motif) receptor 4

CCK

Cholecystokinin

panCK

Pancytokeratin

BrdU

Bromodeoxyuridine

Ly-6

Lymphocyte antigen 6

uPAR

Urokinase-type plasminogen activator receptor

LU

Ly-6 antigen/uPA receptor-like domain

PLA2

Phospholipase A2

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Marcie R. Kritzik
    • 1
    • 4
  • Cory U. Lago
    • 1
    • 5
  • Ayse G. Kayali
    • 1
    • 6
  • Sandrine Arnaud-Dabernat
    • 1
    • 7
  • Guoxun Liu
    • 1
    • 8
  • You-Qing Zhang
    • 1
  • Hong Hua
    • 1
    • 9
  • Howard S. Fox
    • 2
    • 3
  • Nora E. Sarvetnick
    • 1
    • 4
  1. 1.Department of ImmunologyThe Scripps Research InstituteLa JollaUSA
  2. 2.Molecular and Integrative Neuroscience DepartmentThe Scripps Research InstituteLa JollaUSA
  3. 3.Department of Pharmacology and Experimental NeuroscienceLeid Transplant Center, University of Nebraska Medical CenterOmahaUSA
  4. 4.Department of SurgeryLeid Transplant Center, University of Nebraska Medical CenterOmahaUSA
  5. 5.Translational Medicine Branch, National HeartLung, and Blood Institute, National Institutes of HealthBethesdaUSA
  6. 6.The Islet Research Laboratory, Whittier Institute for Diabetes, Department of PediatricsSchool of Medicine, University of California San DiegoLa JollaUSA
  7. 7.Laboratoire de la Biologie de la Differenciation et du DeveloppementUniversity Victor SegalenBordeaux cedexFrance
  8. 8.Genomic Institute of the Novartis Research FoundationSan DiegoUSA
  9. 9.Johnson and Johnson PRDSInternal MedicineSan DiegoUSA