Endocrine

, Volume 36, Issue 3, pp 445–451

Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects

  • Helen Hermana Miranda Hermsdorff
  • M. Ángeles Zulet
  • Itziar Abete
  • J. Alfredo Martínez
Original Article

DOI: 10.1007/s12020-009-9248-1

Cite this article as:
Hermsdorff, H.H.M., Zulet, M.Á., Abete, I. et al. Endocr (2009) 36: 445. doi:10.1007/s12020-009-9248-1

Abstract

Personalized nutritional strategies to treat obesity may specifically influence inflammatory markers, in addition to reduce body weight. In the present study, we evaluated the effect of a hypocaloric diet based on a Mediterranean dietary pattern (MDP) on nutritional status as well as on plasma concentrations of retinol binding protein-4 (RBP4) and other proinflammatory markers. Fourty-one subjects (24F/17M; age: 37 ± 7 years; BMI: 32.2 ± 3.9 kg/m2) were assigned to follow a MDP within a caloric-restricted diet over an 8-week period. Anthropometrical, clinical, and biochemical variables were measured at baseline and endpoint after the nutritional program. Dietary intervention resulted in a mean weight loss of −4.4 ± 2.5 kg (P < 0.001) and marked reductions (P < 0.05) in plasma concentrations of RBP4, leptin, C-reactive protein, complement C3, and tumor necrosis factor-alpha (TNFα). Individuals with a higher adherence to the MDP during the nutritional intervention presented differentially higher reductions (P < 0.05) in plasma RBP4, IL6, and TNFα. In addition, the increase in the Mediterranean diet score from baseline was a significant and independent predictor factor for the decrease in plasma RBP4 concentration (P < 0.05). In conclusion, our findings suggest that following a hypocaloric diet accompanying a high adherence to a MDP resulted in specific reductions on proinflammatory markers, in addition to a significant improvement in some metabolic syndrome features induced by weight loss, which could be a good combined strategy to treat obesity as well as related metabolic and inflammatory disorders.

Keywords

Caloric restrictionMediterranean dietWeight lossInflammationRetinol binding protein-4Complement C3

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Helen Hermana Miranda Hermsdorff
    • 1
  • M. Ángeles Zulet
    • 1
  • Itziar Abete
    • 1
  • J. Alfredo Martínez
    • 1
  1. 1.Department of Nutrition and Food Sciences, Physiology and ToxicologyInstitute of Nutrition and Food Sciences, University of NavarraPamplonaSpain