Endocrine

, Volume 36, Issue 2, pp 268–274

Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients

Authors

  • Menglei Chao
    • Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai UniversitiesRui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
  • Dajin Zou
    • Department of EndocrinologyChang-Hai Hospital affiliated to the Second Military Medical University
  • Yifei Zhang
    • Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai UniversitiesRui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
  • Yuhong Chen
    • Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai UniversitiesRui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
  • Miao Wang
    • Department of EndocrinologyChang-Hai Hospital affiliated to the Second Military Medical University
  • Hong Wu
    • Department of EndocrinologyChang-Hai Hospital affiliated to the Second Military Medical University
  • Guang Ning
    • Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai UniversitiesRui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
    • Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai UniversitiesRui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
    • Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and MetabolismRuijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Original Paper

DOI: 10.1007/s12020-009-9222-y

Cite this article as:
Chao, M., Zou, D., Zhang, Y. et al. Endocr (2009) 36: 268. doi:10.1007/s12020-009-9222-y

Abstract

Some clinical studies and animal researches have evaluated the efficacy of Traditional Chinese Medicine (TCM) and compared its effects with placebo or other antidiabetic drugs. TCM involves three particular plants, as an antidiabetic drug. Our present research planned to evaluate the efficacy of TCM on insulin sensitivity and other related metabolic factors in type 2 diabetic patients. There were 43 newly diagnosed type 2 diabetic patients enrolled in this study, who did not use any antidiabetic drugs before. They were randomly assigned into TCM and placebo groups, administrated with TCM and placebo, respectively. Glucose disposal rate, fasting plasma glucose, postprandial plasma glucose, glycated hemoglobin, and other metabolic components were assessed at baseline and end point. Glucose disposal rate increased from 5.12 ± 2.20 to 6.37 ± 3.51 mg kg−1 min−1 in the TCM group, ANCOVA analysis showed that glucose disposal rate in the TCM group was significantly improved as compared to that in the placebo group (P < 0.05). Other metabolic related components such as fasting plasma glucose, postprandial plasma glucose, glycated hemoglobin, systolic blood pressure, diastolic blood pressure, body mass index, retinol binding protein 4 were improved in TCM group, but no statistical differences was detected between the two groups. No severe side effect was found in TCM group. TCM can ameliorate insulin resistance in type 2 diabetes and it is safe and effective in newly diagnosed diabetic patients.

Keywords

Traditional Chinese medicineType 2 diabetesInsulin resistanceGlucose disposal rate

Abbreviations

T2D

Type 2 diabetes

TCM

Traditional Chinese medicine

FPG

Fasting plasma glucose

PPG

Postprandial plasma glucose

HbA1c

Glycated hemoglobin

INS0’

Fasting plasma insulin

INS120’

Postprandial plasma insulin

TG

Triglyceride

TC

Total cholesterol

HDL-c

High-density lipoprotein-cholesterol

LDL-c

Low-density lipoprotein-cholesterol

HPLC

High performance liquid chromatography

RBP4

Retinol binding protein 4

HsCRP

C-reactive protein

IL-6

Interleukin-6

GDR

Glucose disposal rate

BMI

Body mass index

SBP

Systolic blood pressure

DBP

Diastolic blood pressure

AMPK

AMP-activated protein kinase

Copyright information

© Springer Science+Business Media, LLC 2009