Endocrine

, Volume 36, Issue 1, pp 147–150

Acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto’s thyroiditis

  • Shoko Nakayama
  • Taiji Yokote
  • Kichinosuke Kobayashi
  • Yuji Hirata
  • Tetsuya Hiraiwa
  • Toshikazu Akioka
  • Takuji Miyoshi
  • Takayuki Takubo
  • Motomu Tsuji
  • Toshiaki Hanafusa
Case Report

DOI: 10.1007/s12020-009-9173-3

Cite this article as:
Nakayama, S., Yokote, T., Kobayashi, K. et al. Endocr (2009) 36: 147. doi:10.1007/s12020-009-9173-3

Abstract

We describe a case of acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto’s thyroiditis. In Hashimoto’s thyroiditis, the leukocyte function-associated antigen-1 (LFA-1)/intercellular vascular cell adhesion molecule-1 (ICAM-1) and very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) pathways in T lymphocytes and the vascular endothelium both play a role in the initiation and enhancement of lymphocyte recruitment to the thyroid glands during an autoimmune attack. The leukemic blast cells were positive for VLA-4 and negative for LFA-1 by immunohistochemistry. The presence of VLA-4 in blast cells might play a key role in the migration of blast cells to the thyroid glands.

Keywords

Acute myeloid leukemia Hashimoto’s thyroiditis Infiltration VLA-4 VCAM-1 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Shoko Nakayama
    • 1
  • Taiji Yokote
    • 1
  • Kichinosuke Kobayashi
    • 1
  • Yuji Hirata
    • 1
  • Tetsuya Hiraiwa
    • 1
  • Toshikazu Akioka
    • 1
  • Takuji Miyoshi
    • 1
  • Takayuki Takubo
    • 2
  • Motomu Tsuji
    • 3
  • Toshiaki Hanafusa
    • 1
  1. 1.Department of Internal Medicine (I)Osaka Medical CollegeTakatsuki City, OsakaJapan
  2. 2.Division of Comprehensive Diagnostic and Therapeutics, Department of Clinical and Laboratory MedicineOsaka Medical CollegeTakatsuki City, OsakaJapan
  3. 3.Division of Surgical PathologyOsaka Medical CollegeTakatsuki City, OsakaJapan