Case Report

Endocrine

, Volume 36, Issue 1, pp 147-150

Acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto’s thyroiditis

  • Shoko NakayamaAffiliated withDepartment of Internal Medicine (I), Osaka Medical College Email author 
  • , Taiji YokoteAffiliated withDepartment of Internal Medicine (I), Osaka Medical College
  • , Kichinosuke KobayashiAffiliated withDepartment of Internal Medicine (I), Osaka Medical College
  • , Yuji HirataAffiliated withDepartment of Internal Medicine (I), Osaka Medical College
  • , Tetsuya HiraiwaAffiliated withDepartment of Internal Medicine (I), Osaka Medical College
  • , Toshikazu AkiokaAffiliated withDepartment of Internal Medicine (I), Osaka Medical College
  • , Takuji MiyoshiAffiliated withDepartment of Internal Medicine (I), Osaka Medical College
  • , Takayuki TakuboAffiliated withDivision of Comprehensive Diagnostic and Therapeutics, Department of Clinical and Laboratory Medicine, Osaka Medical College
  • , Motomu TsujiAffiliated withDivision of Surgical Pathology, Osaka Medical College
    • , Toshiaki HanafusaAffiliated withDepartment of Internal Medicine (I), Osaka Medical College

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Abstract

We describe a case of acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto’s thyroiditis. In Hashimoto’s thyroiditis, the leukocyte function-associated antigen-1 (LFA-1)/intercellular vascular cell adhesion molecule-1 (ICAM-1) and very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) pathways in T lymphocytes and the vascular endothelium both play a role in the initiation and enhancement of lymphocyte recruitment to the thyroid glands during an autoimmune attack. The leukemic blast cells were positive for VLA-4 and negative for LFA-1 by immunohistochemistry. The presence of VLA-4 in blast cells might play a key role in the migration of blast cells to the thyroid glands.

Keywords

Acute myeloid leukemia Hashimoto’s thyroiditis Infiltration VLA-4 VCAM-1