, Volume 33, Issue 3, pp 300–304

Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences


    • Endocrinology Section, Department of Internal MedicineUniversity of Chile Clinical Hospital
  • Ximena Orellana
    • Nutrition SectionUniversity of Chile Clinical Hospital
  • Jaime Espinoza
    • Laboratory of Endocrinology and Biology of ReproductionUniversity of Chile Clinical Hospital
Original Paper

DOI: 10.1007/s12020-008-9090-x

Cite this article as:
Araya, A.V., Orellana, X. & Espinoza, J. Endocr (2008) 33: 300. doi:10.1007/s12020-008-9090-x


Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. Objective To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. Subjects Seventeen healthy overweight and obese subjects of both sexes (24–48 years, BMI 34.6 ± 1.1 kg/m2). Methods Anthropometry, oral glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at baseline and at the end of the third month. Reduced-calorie diet was defined as a 25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined sugar was not allowed. Results There was a significant decrease in BMI, waist circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF showed a significant increase (3.97 ± 0.87 to 6.75 ± 1.62 ng/ml, P = 0.02). Final serum BDNF correlated negatively with weight (r = −0.51, P = 0.03), and basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P = 0.04). Conclusions Serum BDNF increases in insulin-resistant overweight and obese subjects after three months on a RCD. This observation could indicate that BDNF may be modulated in humans through diet composition.


Serum BDNFReduced-calorie dietObesityOverweight

Copyright information

© Springer Science+Business Media, LLC 2008