Endocrine

, Volume 33, Issue 2, pp 171–175

Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease

Authors

    • Department of Endocrinology, Metabolism and Diabetes“Metaxa” Memorial Anticancer Research Hospital
    • Department of Growth and Development“P. &. A. Kyriakou” Children’s Hospital
  • Feneli Karachaliou
    • Department of Growth and Development“P. &. A. Kyriakou” Children’s Hospital
  • Konstantina Kallergi
    • Department of Microbiology“P. & A. Kyriakou” Children’s Hospital
  • Elpis Vlachopapadopoulou
    • Department of Growth and Development“P. &. A. Kyriakou” Children’s Hospital
  • Georgia Antonaki
    • Department of Microbiology“P. & A. Kyriakou” Children’s Hospital
  • Fotini Chatzimarkou
    • Department of Endocrinology, Metabolism and Diabetes“Metaxa” Memorial Anticancer Research Hospital
    • Department of Growth and Development“P. &. A. Kyriakou” Children’s Hospital
  • Aspasia Fotinou
    • Department of Microbiology“P. & A. Kyriakou” Children’s Hospital
  • Philippos Kaldrymides
    • Department of Endocrinology, Metabolism and Diabetes“Metaxa” Memorial Anticancer Research Hospital
  • Stefanos Michalacos
    • Department of Growth and Development“P. &. A. Kyriakou” Children’s Hospital
Original Paper

DOI: 10.1007/s12020-008-9068-8

Cite this article as:
Thomas, D., Karachaliou, F., Kallergi, K. et al. Endocr (2008) 33: 171. doi:10.1007/s12020-008-9068-8

Abstract

Background Elevated titers of antibodies against different herpes virus antigens have been reported in some immunodeficient and systemic autoimmune disorders. Objective To examine if Herpes Simplex Virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) IgG and IgM antibodies are detected more frequently in children with autoimmune thyroid disease (AITD) compared to controls. Subjects and methods Thirty-four children with AITD, aged 9.62 ± 2.35 years, and 31 matched controls, aged 9.24 ± 2.98 years, were studied. Results The percentage of EBV IgG+ children with AITD was statistically higher than the percentage of EBV IgG+ controls (82.35% versus 51.61%, P = 0.008). The percentage of EBV IgG+ children with AITD and hypothyroidism was statistically higher than the percentage of EBV IgG+ children with AITD, without hypothyroidism (100% versus 70%, P = 0.024). No other statistically significant differences were observed in HSV−1+2, and CMV IgG or IgM antibodies between the subgroups of children studied. Conclusions EBV seroprevalence is higher in children with AITD compared to controls and the underlying pathology remains to be elucidated.

Keywords

Autoimmune thyroiditisHerpes virusSeroprevalence

Copyright information

© Springer Science+Business Media, LLC 2008