Endocrine

, Volume 31, Issue 2, pp 138–141

The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men

  • Armand Peeters
  • Sigri Beckers
  • Ilse Mertens
  • Wim Van Hul
  • Luc Van Gaal
Original Paper

DOI: 10.1007/s12020-007-0022-y

Cite this article as:
Peeters, A., Beckers, S., Mertens, I. et al. Endocr (2007) 31: 138. doi:10.1007/s12020-007-0022-y

Abstract

Since recent data suggest that the endocannabinoid system controls food intake through central, and lipogenesis via peripheral CB1 receptors, we hypothesized that genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity. We investigated, whether a specific CNR1 G1422A genotype is associated with anthropometric markers of obesity and fat distribution in adult obese individuals. A total of 1,064 obese subjects (BMI ≥ 30 kg/m2) without diabetes, impaired glucose tolerance or other endocrine diseases and 251 healthy control persons were genotyped for the G1422A variant (rs1049353) with a TaqMan assay. Anthropometric measures as body weight, BMI, waist and waist-to-hip ratio (WHR) were assessed by classical methods. Fat mass (FM) was measured by bio-impedance. The prevalence of the G1422A variant was not significantly different between cases and controls (OR = 1.056; P = 0.626). In obese women, no meaningful associations between CNR1 genotype and anthropometric parameters were found. In obese men, CNR1 1422 A/A genotype was significantly associated with higher WHR (P = 0.009) and waist circumference (P = 0.008) after adjusting for age and BMI. Fat mass percentage showed an association (P = 0.011) which disappeared after adjusting for age and BMI. A trend for an association was seen for fat mass (unadjusted P = 0.099; adjusted P = 0.033). Our data indicate that the G1422A polymorphism in the CNR1 gene is associated with increased abdominal adiposity in obese men.

Keywords

AssociationPolymorphismCannabinoid receptorCNR1Obesity

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Armand Peeters
    • 1
  • Sigri Beckers
    • 1
  • Ilse Mertens
    • 2
  • Wim Van Hul
    • 1
  • Luc Van Gaal
    • 2
  1. 1.Department of Medical Genetics, Faculty of Pharmaceutical, Biomedical and Veterinary SciencesAntwerp UniversityWilrijk, AntwerpBelgium
  2. 2.Department of Diabetology, Metabolism and Clinical NutritionAntwerp University HospitalAntwerpBelgium