Original Paper

Endocrine

, Volume 31, Issue 2, pp 138-141

First online:

The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men

  • Armand PeetersAffiliated withDepartment of Medical Genetics, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University Email author 
  • , Sigri BeckersAffiliated withDepartment of Medical Genetics, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University
  • , Ilse MertensAffiliated withDepartment of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital
  • , Wim Van HulAffiliated withDepartment of Medical Genetics, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University
  • , Luc Van GaalAffiliated withDepartment of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital

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Abstract

Since recent data suggest that the endocannabinoid system controls food intake through central, and lipogenesis via peripheral CB1 receptors, we hypothesized that genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity. We investigated, whether a specific CNR1 G1422A genotype is associated with anthropometric markers of obesity and fat distribution in adult obese individuals. A total of 1,064 obese subjects (BMI ≥ 30 kg/m2) without diabetes, impaired glucose tolerance or other endocrine diseases and 251 healthy control persons were genotyped for the G1422A variant (rs1049353) with a TaqMan assay. Anthropometric measures as body weight, BMI, waist and waist-to-hip ratio (WHR) were assessed by classical methods. Fat mass (FM) was measured by bio-impedance. The prevalence of the G1422A variant was not significantly different between cases and controls (OR = 1.056; P = 0.626). In obese women, no meaningful associations between CNR1 genotype and anthropometric parameters were found. In obese men, CNR1 1422 A/A genotype was significantly associated with higher WHR (P = 0.009) and waist circumference (P = 0.008) after adjusting for age and BMI. Fat mass percentage showed an association (P = 0.011) which disappeared after adjusting for age and BMI. A trend for an association was seen for fat mass (unadjusted P = 0.099; adjusted P = 0.033). Our data indicate that the G1422A polymorphism in the CNR1 gene is associated with increased abdominal adiposity in obese men.

Keywords

Association Polymorphism Cannabinoid receptor CNR1 Obesity