, Volume 32, Issue 3, pp 182-188

Use of antiplatelet drugs in secondary prevention in patients with atherothrombotic disease

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Unless there are contraindications to the use of aspirin, aspirin should be used to treat patients with acute myocardial infarction (MI) and continued indefinitely to decrease vascular death, nonfatal MI, and nonfatal stroke. Chlopidogrel added to aspirin is beneficial in the treatment of patients with acute ST-elevation MI. Patients with unstable angina pectoris or non-ST-elevation MI should be treated with aspirin plus clopindogrel for at least 9 mo to decease vascular death, nonfatal MI, and nonfatal stroke. Patients with prior MI should be treated indefinitely with aspirin and with clopidogrel if aspirin is contraindicated. Patients with ischemic stroke should be treated with either aspirin or clopidogrel indefinitely. Clopidogrel is significantly more effective than aspirin in reducing vascular death, nonfatal MI, and nonfatal stroke in patients with peripheral arterial disease

The author ha stated that be does not have a significant financial interest or other relationship with any product manufacture or provider of services dis-cussed in this article. The author does not discuss the use of off-label, products, which includes unlabed, unapproved, or investigative products or devices.