Bone and Muscle Pleiotropy: The Genetics of Associated Traits

Original Paper

DOI: 10.1007/s12018-014-9159-4

Cite this article as:
Blank, R.D. Clinic Rev Bone Miner Metab (2014) 12: 61. doi:10.1007/s12018-014-9159-4


Bone and muscle mass are highly correlated. In part, this is a consequence of both tissues sharing common genetic determinants. In addition, both tissues are responsive to their mechanical environments. New genetic tools in mice will allow genes of interest to be inactivated in experimentally defined contexts, thus allowing investigators to distinguish direct effects on each tissue from physiological responses to a primary phenotype in the other.


Conditional knockout miceMechanobiologyBone modelingExercise

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Clement J. Zablocki VAMCMilwaukeeUSA