Osteocyte Communication with the Kidney Via the Production of FGF23: Remote Control of Phosphate Homeostasis
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- Ito, N., Findlay, D.M. & Atkins, G.J. Clinic Rev Bone Miner Metab (2014) 12: 44. doi:10.1007/s12018-014-9155-8
Osteocytes have emerged as the principal controlling cell type in bone. It is now clear that osteocytes communicate with each other, with other key bone cell types and also function as a vital endocrine organ. In this review, we will focus on one such humoral factor produced by osteocytes, fibroblast growth factor 23 and the involvement of this key phosphate-regulating hormone in human disease.