Clinical Reviews in Bone and Mineral Metabolism

, Volume 12, Issue 1, pp 44–58

Osteocyte Communication with the Kidney Via the Production of FGF23: Remote Control of Phosphate Homeostasis

Authors

  • Nobuaki Ito
    • Bone Cell Biology Group, Centre for Orthopaedic and Trauma ResearchThe University of Adelaide
  • David M. Findlay
    • Bone Cell Biology Group, Centre for Orthopaedic and Trauma ResearchThe University of Adelaide
    • Bone Cell Biology Group, Centre for Orthopaedic and Trauma ResearchThe University of Adelaide
Original Paper

DOI: 10.1007/s12018-014-9155-8

Cite this article as:
Ito, N., Findlay, D.M. & Atkins, G.J. Clinic Rev Bone Miner Metab (2014) 12: 44. doi:10.1007/s12018-014-9155-8

Abstract

Osteocytes have emerged as the principal controlling cell type in bone. It is now clear that osteocytes communicate with each other, with other key bone cell types and also function as a vital endocrine organ. In this review, we will focus on one such humoral factor produced by osteocytes, fibroblast growth factor 23 and the involvement of this key phosphate-regulating hormone in human disease.

Keywords

FGF23OsteocyteHormonePhosphateHypophosphataemiaRicketsOsteomalacia

Copyright information

© Springer Science+Business Media New York 2014