Use of Bone Turnover Markers in Osteoporosis

Original Paper

DOI: 10.1007/s12018-009-9042-x

Cite this article as:
Lenora, J., Ivaska, K.K. & Gerdhem, P. Clinic Rev Bone Miner Metab (2010) 8: 1. doi:10.1007/s12018-009-9042-x


Bone metabolism can be assessed by measuring bone turnover markers in serum or urine. Bone turnover markers are substances released from bone during bone turnover. They can be skeletal tissue proteins, collagen fragments, peptides, or enzymes released from bone cells. Bone turnover markers are extensively used in research applications but also as tools for the management of skeletal disorders in clinical practice. Osteoporosis-related applications may include assessment of response to, or deciding on osteoporosis therapy; identification of individuals with increased bone loss, and prediction of risk for fragility fractures. Advancements in the development of assays to measure bone markers has made the measurements available also for clinical practice. The possibility to use them in various aspects of clinical practice has been tested in the recent years and given promising results. Monitoring the efficacy of bone-active drugs is currently the most promising application for bone turnover markers. Some markers, particularly resorption markers may also be useful in identifying individuals who are at high risk for bone loss and future fracture. In this article we discuss some potential applications of currently available bone turnover markers in postmenopausal osteoporosis.


Osteoporosis Bone turnover markers Clinical utility Bone mineral density Bone loss Fracture prediction Treatment monitoring 

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Janaka Lenora
    • 1
    • 2
  • Kaisa K. Ivaska
    • 1
    • 2
    • 3
  • Paul Gerdhem
    • 1
    • 2
    • 4
  1. 1.Department of Orthopaedics, Clinical and Molecular Osteoporosis Research UnitMalmö University Hospital, Lund UniversityMalmöSweden
  2. 2.Department of Clinical Sciences, Clinical and Molecular Osteoporosis Research UnitMalmö University Hospital, Lund UniversityMalmöSweden
  3. 3.Department of Cell Biology and Anatomy, Institute of BiomedicineUniversity of TurkuTurkuFinland
  4. 4.Departments of Orthopaedics, K 54, Department of Clinical Sciences and InterventionKarolinska University Hospital, Karolinska InstituteStockholmSweden