mTOR Signaling in Parkinson’s Disease

  • Ai-ping Lan
  • Jun Chen
  • Yuliang Zhao
  • Zhifang Chai
  • Yi Hu
Review Paper

DOI: 10.1007/s12017-016-8417-7

Cite this article as:
Lan, A., Chen, J., Zhao, Y. et al. Neuromol Med (2016). doi:10.1007/s12017-016-8417-7

Abstract

As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.

Keywords

mTORParkinson’s diseaseApoptosisα-SynucleinOxidative stress

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Ai-ping Lan
    • 1
  • Jun Chen
    • 1
  • Yuliang Zhao
    • 1
  • Zhifang Chai
    • 1
  • Yi Hu
    • 1
  1. 1.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy PhysicsChinese Academy of Sciences (CAS)BeijingChina