NeuroMolecular Medicine

, Volume 10, Issue 1, pp 40–45

DJ-1 is Essential for Long-Term Depression at Hippocampal CA1 Synapses

  • Yue Wang
  • Jayanth S. Chandran
  • Huaibin Cai
  • Mark P. Mattson
Original Paper

DOI: 10.1007/s12017-008-8023-4

Cite this article as:
Wang, Y., Chandran, J.S., Cai, H. et al. Neuromol Med (2008) 10: 40. doi:10.1007/s12017-008-8023-4

Abstract

Mutations in DJ-1 cause inherited Parkinson’s disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1−/− mice, whereas DJ-1+/− mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1−/− mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.

Keywords

DJ-1LTDLTPParkinson’s diseaseDopamine receptorHippocampal CA1

Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Yue Wang
    • 1
    • 2
  • Jayanth S. Chandran
    • 3
  • Huaibin Cai
    • 3
  • Mark P. Mattson
    • 1
    • 4
  1. 1.Laboratory of NeurosciencesNational Institute on Aging Intramural Research ProgramBaltimoreUSA
  2. 2.Laboratory of NeurosciencesNational Institute on Aging Gerontology Research CenterBaltimoreUSA
  3. 3.Laboratory of NeurogeneticsNational Institute on Aging Intramural Research ProgramBaltimoreUSA
  4. 4.Department of NeuroscienceJohns Hopkins University School of MedicineBaltimoreUSA