DJ-1 is Essential for Long-Term Depression at Hippocampal CA1 Synapses
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- Wang, Y., Chandran, J.S., Cai, H. et al. Neuromol Med (2008) 10: 40. doi:10.1007/s12017-008-8023-4
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Mutations in DJ-1 cause inherited Parkinson’s disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relatively high levels of DJ-1, and PD patients are often cognitively impaired, we evaluated the effects of DJ-1 deficiency on the plasticity of hippocampal CA1 synapses. LTP was slightly impaired and LTD was abolished in DJ-1−/− mice, whereas DJ-1+/− mice exhibited no alterations in synaptic plasticity. The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1−/− mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit.