Clinical Reviews in Allergy & Immunology

, Volume 46, Issue 2, pp 101–103

Historical Perspectives in the Diagnosis and Treatment of Primary Immune Deficiencies

Article

DOI: 10.1007/s12016-013-8384-9

Cite this article as:
Ballow, M. Clinic Rev Allerg Immunol (2014) 46: 101. doi:10.1007/s12016-013-8384-9

Abstract

The field of Primary Immune Deficiency Disorders (PIDD) has advanced rapidly over the past several years with over 200 different gene mutations defined. With the recent institution of newborn screening for T cell deficiencies in many states and earlier recognition of the signs and symptoms of patients with immune deficiency, it is now apparent that PIDD is not as “rare” as was originally thought several decades ago. With the earlier recognition of patients with recurrent infections and various immune perturbations, advancements in the treatment of these immune deficiency disorders have led to enhanced survival and quality of life. In this issue, the diagnosis of PIDD through laboratory testing and skin manifestations is reviewed. The more recently described cellular immune deficiencies, selective immune deficiencies, and advances in the use of bone marrow transplantation in the correction of some of these immune deficiencies are discussed.

Keywords

Primary immune deficiencyNewborn screeningSevere combined immunodeficiencyGene mutations

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Allergy and Clinical ImmunologyWomen and Children’s Hospital of Buffalo, SUNY Buffalo, School of Medicine and Biomedical SciencesBuffaloUSA
  2. 2.Department of PediatricsWomen and Children’s Hospital of Buffalo, SUNY Buffalo, School of Medicine and Biomedical SciencesBuffaloUSA
  3. 3.Division of Allergy, Immunology and Pediatric RheumatologyUniversity of South Florida, College of MedicineSt. PetersburgUSA