Clinical Reviews in Allergy & Immunology

, Volume 42, Issue 2, pp 154–163

Geographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adults

  • Yinon Shapira
  • Bat-Sheva PoratKatz
  • Boris Gilburd
  • Ori Barzilai
  • Maya Ram
  • Miri Blank
  • Staffan Lindeberg
  • Johan Frostegård
  • Juan-Manuel Anaya
  • Nicola Bizzaro
  • Luis J. Jara
  • Jan Damoiseaux
  • Yehuda Shoenfeld
  • Nancy Agmon Levin
Article

DOI: 10.1007/s12016-010-8241-z

Cite this article as:
Shapira, Y., PoratKatz, BS., Gilburd, B. et al. Clinic Rev Allerg Immunol (2012) 42: 154. doi:10.1007/s12016-010-8241-z

Abstract

Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. Sera samples from 557 healthy donors were obtained at six centers located in different countries (i.e., Italy, Netherlands, Israel, Mexico, Columbia, Papua New Guinea (Kitavans)). Sera were tested for the presence of antinuclear antibodies (ANA) and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal (GI) disease. Sera samples were also screened for antibodies against infectious agents (i.e., EBV, CMV, HBV, Helicobacter pylori, Treponema pallidum, and Toxoplasma gondii). Tests were performed using the BioPlex 2200 or ELISA kits (Bio-Rad Laboratories, USA). We found a significant gradient of ANA positivity among the groups: 45% of Columbians, 38% of Kitavans, 26% of Mexicans, 12% of Italians, 12% of Dutch, and 11% of Israelis were ANA positive. Geographical differences were also observed regarding the prevalence of specific autoantibodies, namely ANA: anti-dsDNA, chromatin, SmRNP, Ro/SSA, La/SSB, Scl70; GI associated: antigliadin; and thrombophilia-associated: anti-β2GP1 and prothrombin. Additionally, significant differences were observed regarding serological markers of all infectious agents screened. The observed variance between healthy ethno-geographical distinct populations in prevalence of autoantibodies may represent different genetic or environmental (e.g., prior exposure to infection) influences. Thus may illuminate possible causes of geoepidemiological differences in AD.

Keywords

Autoimmunity Geoepidemiology Ethnicity Antinuclear antibodies Antigliadin Antiphospholipid antibodies Infectious agents 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yinon Shapira
    • 1
  • Bat-Sheva PoratKatz
    • 2
  • Boris Gilburd
    • 1
  • Ori Barzilai
    • 1
  • Maya Ram
    • 1
  • Miri Blank
    • 1
  • Staffan Lindeberg
    • 3
  • Johan Frostegård
    • 4
  • Juan-Manuel Anaya
    • 5
  • Nicola Bizzaro
    • 6
  • Luis J. Jara
    • 7
  • Jan Damoiseaux
    • 8
  • Yehuda Shoenfeld
    • 1
    • 9
    • 10
  • Nancy Agmon Levin
    • 1
    • 9
  1. 1.The Zabludowicz Center for Autoimmune DiseasesSheba Medical CenterTel HashomerIsrael
  2. 2.Faculty of Agricultural, Food and Environmental Quality SciencesThe Hebrew UniversityRehovotIsrael
  3. 3.University of LundLundSweden
  4. 4.Department of MedicineKarolinska University HospitalStockholmSweden
  5. 5.Center for Autoimmune Diseases ResearchRosario University MedellinMedellinColombia
  6. 6.Laboratorio di Patologia ClinicaTolmezzoItaly
  7. 7.Hospital de especialidadesCentro Medico La RazaColoniaMexico
  8. 8.Laboratory of Clinical ImmunologyMaastricht University Medical CenterMaastrichtthe Netherlands
  9. 9.Department of Medicine ‘B’Sheba Medical CenterTel HashomerIsrael
  10. 10.Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune DiseasesTel-Aviv UniversityTel-AvivIsrael

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