Article

Clinical Reviews in Allergy & Immunology

, Volume 39, Issue 1, pp 85-94

Autoreactive B Cells and Epigenetics

  • Yves RenaudineauAffiliated withEA2216 Immunology and Pathology, IFR 148 ScInBioS, Université de Brest, Université Européenne de BretagneLaboratory of Immunology, CHU Brest, Hôpital MorvanLaboratory of Immunology, Brest University Medical School Hospital Email author 
  • , Soizic GaraudAffiliated withEA2216 Immunology and Pathology, IFR 148 ScInBioS, Université de Brest, Université Européenne de Bretagne
  • , Christelle Le DantecAffiliated withEA2216 Immunology and Pathology, IFR 148 ScInBioS, Université de Brest, Université Européenne de Bretagne
  • , Ruby Alonso-RamirezAffiliated withEA2216 Immunology and Pathology, IFR 148 ScInBioS, Université de Brest, Université Européenne de BretagneExperimental Immunotherapy Department, Center for Molecular Immunology
  • , Capucine DaridonAffiliated withEA2216 Immunology and Pathology, IFR 148 ScInBioS, Université de Brest, Université Européenne de BretagneLaboratory of Immunology, CHU Brest, Hôpital Morvan
  • , Pierre YouinouAffiliated withEA2216 Immunology and Pathology, IFR 148 ScInBioS, Université de Brest, Université Européenne de BretagneLaboratory of Immunology, CHU Brest, Hôpital Morvan

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Abstract

Autoreactive B cells are central in the pathogenesis of autoimmune diseases (AID) not only by producing autoantibodies but also by secreting cytokines and by presenting autoantigens. Changes in DNA methylation, histone modifications, and miRNA expression, the hallmarks of epigenetic failure, characterize B cells isolated from patients with AID, highlighting the contribution of epigenetic processes to autoreactivity. Additional evidence of epigenetic involvement in the development of B cell autoreactivity comes from in vivo and in vitro studies using DNA demethylating agents as accelerating factors or histone deacetylase inhibitors as repressing factors. As a result, a better understanding of the altered epigenetic processes in AID and in particular in B cells opens perspectives for the development of new therapeutics.

Keywords

B cells Epigenetic Autoimmunity Systemic lupus erythematosus