Clinical Reviews in Allergy & Immunology

, Volume 39, Issue 1, pp 85–94

Autoreactive B Cells and Epigenetics

  • Yves Renaudineau
  • Soizic Garaud
  • Christelle Le Dantec
  • Ruby Alonso-Ramirez
  • Capucine Daridon
  • Pierre Youinou
Article

DOI: 10.1007/s12016-009-8174-6

Cite this article as:
Renaudineau, Y., Garaud, S., Le Dantec, C. et al. Clinic Rev Allerg Immunol (2010) 39: 85. doi:10.1007/s12016-009-8174-6
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Abstract

Autoreactive B cells are central in the pathogenesis of autoimmune diseases (AID) not only by producing autoantibodies but also by secreting cytokines and by presenting autoantigens. Changes in DNA methylation, histone modifications, and miRNA expression, the hallmarks of epigenetic failure, characterize B cells isolated from patients with AID, highlighting the contribution of epigenetic processes to autoreactivity. Additional evidence of epigenetic involvement in the development of B cell autoreactivity comes from in vivo and in vitro studies using DNA demethylating agents as accelerating factors or histone deacetylase inhibitors as repressing factors. As a result, a better understanding of the altered epigenetic processes in AID and in particular in B cells opens perspectives for the development of new therapeutics.

Keywords

B cellsEpigeneticAutoimmunitySystemic lupus erythematosus

Abbreviations

AID

Autoimmune diseases

SLE

Systemic lupus erythematosus

RA

Rheumatoid arthritis

DNMT

DNA methyltransferase

HDAC

Histone deacetylase

miR

MicroRNA

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Yves Renaudineau
    • 1
    • 3
    • 4
  • Soizic Garaud
    • 1
  • Christelle Le Dantec
    • 1
  • Ruby Alonso-Ramirez
    • 1
    • 2
  • Capucine Daridon
    • 1
    • 3
  • Pierre Youinou
    • 1
    • 3
  1. 1.EA2216 Immunology and Pathology, IFR 148 ScInBioSUniversité de Brest, Université Européenne de BretagneBrestFrance
  2. 2.Experimental Immunotherapy DepartmentCenter for Molecular ImmunologyHavanaCuba
  3. 3.Laboratory of Immunology, CHU BrestHôpital MorvanBrestFrance
  4. 4.Laboratory of ImmunologyBrest University Medical School HospitalBrestFrance