Pregnancy and Catastrophic Antiphospholipid Syndrome
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- Gómez-Puerta, J.A., Sanin-Blair, J. & Galarza-Maldonado, C. Clinic Rev Allerg Immunol (2009) 36: 85. doi:10.1007/s12016-008-8100-3
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Antiphospholipid syndrome (APS) is clearly related to maternal morbidity. The most characteristic feature is pregnancy loss; however, several other serious complications had been reported including fetal growth restriction, uteroplacental insufficiency, fetal distress, pre-eclampsia, and HELLP syndrome. Herein, we review the different aspects of obstetric APS features, with special emphasis on its life-threatening variant known as catastrophic APS (Asherson’s syndrome) and its relationship with a thrombotic microangiopathy such as HELLP syndrome.