Clinical Reviews in Allergy & Immunology

, Volume 36, Issue 2, pp 85–90

Pregnancy and Catastrophic Antiphospholipid Syndrome

  • Jose A. Gómez-Puerta
  • Jose Sanin-Blair
  • Claudio Galarza-Maldonado

DOI: 10.1007/s12016-008-8100-3

Cite this article as:
Gómez-Puerta, J.A., Sanin-Blair, J. & Galarza-Maldonado, C. Clinic Rev Allerg Immunol (2009) 36: 85. doi:10.1007/s12016-008-8100-3


Antiphospholipid syndrome (APS) is clearly related to maternal morbidity. The most characteristic feature is pregnancy loss; however, several other serious complications had been reported including fetal growth restriction, uteroplacental insufficiency, fetal distress, pre-eclampsia, and HELLP syndrome. Herein, we review the different aspects of obstetric APS features, with special emphasis on its life-threatening variant known as catastrophic APS (Asherson’s syndrome) and its relationship with a thrombotic microangiopathy such as HELLP syndrome.


Antiphospholipid syndromeCatastrophic antiphospholipid syndromeHELLP syndromePre-eclampsia

Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Jose A. Gómez-Puerta
    • 1
  • Jose Sanin-Blair
    • 2
  • Claudio Galarza-Maldonado
    • 3
  1. 1.Rheumatology DepartmentHospital ClínicBarcelonaSpain
  2. 2.Maternal-Fetal Medicine UnitUniversidad Pontificia Bolivariana-Grupo GIE-SHAEMedellínColombia
  3. 3.Rheumatic and Autoimmune disease Unit, UNERAHospital Monte SinaiCuencaEcuador