Clinical Reviews in Allergy & Immunology

, Volume 34, Issue 3, pp 321–325

Anti-α-Actinin Antibodies Cross-react with Anti-ssDNA Antibodies in Active Autoimmune Hepatitis

Authors

  • Yves Renaudineau
    • Brest University Medical School Hospital
  • Geogios N. Dalekos
    • Thessaly University Medical School
  • Paul Guéguen
    • Brest University Medical School Hospital
  • Kalliopi Zachou
    • Thessaly University Medical School
    • Brest University Medical School Hospital
    • Laboratory of ImmunologyBrest University Medical School Hospital
Article

DOI: 10.1007/s12016-007-8050-1

Cite this article as:
Renaudineau, Y., Dalekos, G.N., Guéguen, P. et al. Clinic Rev Allerg Immunol (2008) 34: 321. doi:10.1007/s12016-007-8050-1

Abstract

Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-α-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Guéguen et al., J Clin Immunol 26:495–505, 2006). As anti-α-actinin Abs are also associated with anti-single-stranded (ss) DNA in 16 of 50 (32%) AIH-1 patients, compared with 16 of 401 (4.0%) liver disease control patients, we sought to characterize these Abs in AIH-1. When associated, anti-ssDNA Abs cross-react with anti-α-actinin Abs, but neither with anti-double-stranded DNA Abs nor with anti-F-actin Abs. Furthermore, anti-α-actinin Abs are associated with high-avidity anti-ssDNA Abs in AIH-1. In addition, double reactivity against α-actinin and ssDNA was correlated with clinical and histological activity of the disease and untreated AIH-1 patients.

Keywords

Autoimmune hepatitis type 1Anti-DNAAnti-α-actinin

Copyright information

© Humana Press Inc. 2007