Clinical Reviews in Allergy & Immunology

, Volume 34, Issue 1, pp 85-102

First online:

Hepatitis B Virus (HBV) and Autoimmune Disease

  • Ram MayaAffiliated withDepartment of Medicine ‘B’ & Center for Autoimmune Diseases, Chaim Sheba Medical Center
  • , M. Eric GershwinAffiliated withDivision of Rheumatology, Allergy and Clinical Immunology, University of California
  • , Yehuda ShoenfeldAffiliated withDepartment of Medicine ‘B’ & Center for Autoimmune Diseases, Chaim Sheba Medical CenterSackler Faculty of Medicine, Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The etiology and pathogenesis of autoimmune diseases have long been an enigmatic subject that have involved genetic and environmental factors. Recent intriguing data has contributed to the mechanisms involved, including the relationship of infectious agents and loss of tolerance. This loss of tolerance is illustrated by the data on the immune response to Hepatitis B virus such as the molecular mimicry between HBV antigens and self proteins, the generation of immune complexes between HBV antigens and antibodies, and apoptosis/tissue damage resulting in the exposure of intracellular antigens to the immune system. In this paper, we review the current database related to HBV infection and a variety of autoimmune conditions, including autoimmune hepatitis, systemic lupus erythematosus, aplastic anemia, antiphospholipid syndrome, polyarteritis nodosa, rheumatoid arthritis, type 1 diabetes, multiple sclerosis, thyroid disease and uveitis.


Hepatitis B virus Autoimmune disease Autoimmune hepatitis Systemic lupus erythomatosus Antiphospholipid syndrome Polyarteritis nodosa Rheumatoid arthritis Type 1 diabetes Multiple sclerosis Thyroid disease and uveitis