Clinical Reviews in Allergy & Immunology

, Volume 33, Issue 3, pp 191–198

Cellular Aspects of Atopic Dermatitis

Article

DOI: 10.1007/s12016-007-0045-4

Cite this article as:
Ou, LS. & Huang, JL. Clinic Rev Allerg Immunol (2007) 33: 191. doi:10.1007/s12016-007-0045-4

Abstract

Atopic dermatitis (AD) is a highly pruritic, chronic, and relapsing inflammatory skin disease. Recent interest in AD has been sparked by reports of its increasing prevalence and its contribution to increasing health care costs. A precise understanding of immunologic mechanisms is crucial for the development of effective treatment strategies for AD. Various studies reveal that AD has a multifactorial cause with the activation of complex immunologic and inflammatory pathways. This review will discuss cellular-mediated immunological pathomechanisms of AD. Emphasis will be given to the role played by T cells, antigen-presenting cells, eosinophils, and keratinocytes. We also examine the immunological effect of superantigens on various inflammatory cells including T regulatory cells.

Keywords

Atopic dermatitisT cellAntigen-presenting cellEosinophilKeratinocyteSuperantigensT regulatory cell

Abbreviations

AD

atopic dermatitis

APC

antigen-presenting cell

LC

Langerhans’ cell

GM-CSF

granulocyte–macrophage colony-stimulating factor

CLA

cutaneous lymphocyte-associated antigen

SAg

superantigen

DC

dendritic cell

FcɛRI

high-affinity receptor for IgE

FcɛRII

low-affinity receptor for IgE

IDEC

inflammatory dendritic epidermal cell

MCP

monocyte chemoattractant protein

TARC

thymus and activation-regulated chemokine

pDC

plasmacytoid dendritic cell

MBP

major basic protein

EPD

eosinophil peroxidase

ECP

eosinophil cationic protein

EDN

eosinophil-derived neurotoxin

LT

leukotriene

PAF

platelet-activating factor

MCP

monocyte chemotactic protein

TNF

tumor necrosis factor

Treg cell

T regulatory cell

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  1. 1.Division of Allergy, Asthma and Rheumatology Department of PediatricsChang Gung Children’s Hospital, Chang Gung UniversityTaoyuanRepublic of China