Stem Cell Reviews and Reports

, Volume 10, Issue 5, pp 686–696

Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration

  • Wei Seong Toh
  • Casper Bindzus Foldager
  • Ming Pei
  • James Hoi Po Hui
Article

DOI: 10.1007/s12015-014-9526-z

Cite this article as:
Toh, W.S., Foldager, C.B., Pei, M. et al. Stem Cell Rev and Rep (2014) 10: 686. doi:10.1007/s12015-014-9526-z

Abstract

Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.

Keywords

Stem cells Mesenchymal stem cells Secretome Extracellular matrix Cartilage Biomaterials Tissue regeneration Tissue engineering 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Wei Seong Toh
    • 1
    • 2
  • Casper Bindzus Foldager
    • 3
  • Ming Pei
    • 4
  • James Hoi Po Hui
    • 2
    • 5
  1. 1.Faculty of DentistryNational University of SingaporeSingaporeSingapore
  2. 2.Tissue Engineering Program, Life Sciences InstituteNational University of SingaporeSingaporeSingapore
  3. 3.Orthopaedic Research LaboratoryAarhus University HospitalAarhus CDenmark
  4. 4.Stem Cell and Tissue Engineering Laboratory, Department of OrthopaedicsWest Virginia UniversityMorgantownUSA
  5. 5.Cartilage Repair Program, Therapeutic Tissue Engineering Laboratory, Department of Orthopaedic SurgeryNational University Health System, National University of SingaporeSingaporeSingapore