Stem Cell Reviews and Reports

, Volume 10, Issue 1, pp 127–144

Seeing Stem Cells at Work In Vivo

Article

DOI: 10.1007/s12015-013-9468-x

Cite this article as:
Srivastava, A.K. & Bulte, J.W.M. Stem Cell Rev and Rep (2014) 10: 127. doi:10.1007/s12015-013-9468-x

Abstract

Stem cell based-therapies are novel therapeutic strategies that hold key for developing new treatments for diseases conditions with very few or no cures. Although there has been an increase in the number of clinical trials involving stem cell-based therapies in the last few years, the long-term risks and benefits of these therapies are still unknown. Detailed in vivo studies are needed to monitor the fate of transplanted cells, including their distribution, differentiation, and longevity over time. Advancements in non-invasive cellular imaging techniques to track engrafted cells in real-time present a powerful tool for determining the efficacy of stem cell-based therapies. In this review, we describe the latest approaches to stem cell labeling and tracking using different imaging modalities.

Keywords

Stem cells Cell labeling Cellular imaging Reporter genes Nanoparticles 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Russell H. Morgan Department of Radiology and Radiological Science, Division of MR ResearchThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Cellular Imaging Section, Institute for Cell EngineeringThe Johns Hopkins University School of MedicineBaltimoreUSA

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