Stem Cell Reviews and Reports

, Volume 7, Issue 2, pp 238–247

Functional Characterization of Stem Cell Activity in the Mouse Mammary Gland

Article

DOI: 10.1007/s12015-010-9191-9

Cite this article as:
Bruno, R.D. & Smith, G.H. Stem Cell Rev and Rep (2011) 7: 238. doi:10.1007/s12015-010-9191-9

Abstract

Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.

Keywords

Stem cellsMammary glandNicheLabel-retaining cellsAsymmetric DNA segregationParity identified mammary epithelial cellsLobule progenitorDuctal progenitor

Copyright information

© US Government 2010

Authors and Affiliations

  1. 1.Mammary Biology and Tumorigenesis Laboratory, Center for Cancer ResearchNational Cancer InstituteBethesdaUSA