, Volume 5, Issue 4, pp 301-314
Date: 17 Dec 2009

Consensus Guidance for Banking and Supply of Human Embryonic Stem Cell Lines for Research Purposes

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Background and Scope

In just a few years hundreds of human embryonic stem cell (hESC) lines have been established in laboratories around the world and many programmes of research initiated to investigate their properties and broad ranging potential in therapy and for other research applications, such as developmental biology, toxicology and drug discovery. This work is being performed with a variety of cell lines using a variety of culture conditions; a situation that makes standardisation between projects and publications very difficult and could prevent the identification of cells that have undergone permanent deleterious changes. Clearly the consequence of using such cells would be wasted time and resources but, more seriously, the generation of erroneous data in the literature which could both confuse and delay scientific progress in this area. Thus ensuring that cell lines used in this dynamic field have the correct identity and characteristics is critical to the delivery of effect ...

The complete list of contributors to the International Stem Cell Banking Initiative are listed at the end of the paper. Correspondance should be directed to G Stacey at Glyn.Stacey@nibsc.hpa.org.uk