Article

Stem Cell Reviews and Reports

, Volume 5, Issue 3, pp 266-277

Cord Blood—An Alternative Source for Bone Regeneration

  • Marcus JägerAffiliated withDepartment of Orthopaedics, Heinrich-Heine University Medical School Email author 
  • , Christoph ZilkensAffiliated withDepartment of Orthopaedics, Heinrich-Heine University Medical School
  • , Bernd BittersohlAffiliated withDepartment of Orthopaedics, Heinrich-Heine University Medical School
  • , Rüdiger KrauspeAffiliated withDepartment of Orthopaedics, Heinrich-Heine University Medical School

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Abstract

Bone regeneration is one of the best investigated pathways in mesenchymal stromal cell (MSC) biology. Therfore strong efforts have been made to introduce tissue engineering and cell therapeutics as an alternative treatement option for patients with bone defects. This review of the literature gives an overview of MSC biology aiming for clinical application including advantages but also specific challenges and problems which are associated with cord blood derived stromal cell (CB-MSC) as a source for bone regeneration. The use of postnatal CB-MSC is ethically uncomplicated and requires no invasive harvesting procedure. Moreover, most data document a high osteogenic potential of CB-MCS and also low immunoreactivity compared with other MSC types. The expression profile of CB-MSC during osteogenic differentiation shows similarities to that of other MSC types. Within the umbilical cord different MSC types have been characterized which are potent to differentiate into osteoblasts. In contrast to a large number of in vitro investigations there are only few in vivo studies avaiable so far.

Keywords

Cord blood Mesenchymal stromal cell Osteoblast Bone defect