Stem Cell Reviews

, Volume 2, Issue 3, pp 247–254

Corneal epithelial stem cells in health and disease

Article

DOI: 10.1007/s12015-006-0053-4

Cite this article as:
Daniels, J.T., Harris, A.R. & Mason, C. Stem Cell Rev (2006) 2: 247. doi:10.1007/s12015-006-0053-4

Abstract

The cornea on the front surface of the eye provides our window to the world. Maintenance of corneal transparency is dependent on the integrity and functionality of the outermost corneal epithelium which itself is maintained throughout life by a population of limbal epithelial stem cells (LESC). If this adult stem cell population is depleted by injury or disease, the transparency of the cornea and therefore vision is threatened. LESC deficiency results in corneal opacification, inflammation, vascularization, and severe discomfort. Cultured LESC therapy is one of only several examples of the successful use of an adult stem cell therapy in patients. Hence, the ready accessibility of a transparent stem cell niche and the clinical precedence for use of stem cell therapy make the cornea a unique and excellent model for the study of adult stem cells in health and disease. This review will discuss our current understanding of LESC biology, pathology, and therapeutic application.

Index Entries

Cornea stem cells limbus corneal epithelium limbal epithelial stem cells 

Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  • Julie T. Daniels
    • 1
  • Anna R. Harris
    • 1
    • 2
  • Chris Mason
    • 2
  1. 1.Cells for Sight Transplantation and Research Programme, Ocular Repair and Regeneration Biology Unit, Division of PathologyUCL Institute of OphthalmologyLondon
  2. 2.Regenerative Medicine Bioprocessing Unit, Advanced Centre for Biochemical EngineeringUniversity College LondonLondon

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