Original Article

Stem Cell Reviews

, Volume 2, Issue 2, pp 133-141

First online:

Amnion-derived pluripotent/multipotent stem cells

  • Toshio MikiAffiliated withDepartment of Pathology, University of Pittsburgh
  • , Stephen C. StromAffiliated withDepartment of Pathology, University of Pittsburgh Email author 

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Amniotic epithelium is derived from the epiblast by approx 8 d after fertilization. Other parts of the placenta are derived from extraembryonic tissue. In addition to this developmental difference, amniotic epithelial (AE) cells are known to have unique characteristics, such as low level expression of major histocompatibility complex antigens, and a less restricted differentiation potential. The differentiation of the AE cells to the neural lineage is well documented. Recently, we reported that AE cells from term placenta express several stem cell surface markers that are commonly found on pluripotent stem cells such as embryonic stem cells, and that in culture, AE cells differentiate into cell types from all three germ layers. In this review, we describe the unique characteristics of the AE stem cells and summarize previous work concerning the stem cell nature of cells from amnion.

Index Entries

Amnion pluripotent stem cell Oct-4 placenta