Clinical Investigation of Fasudil for the Prevention of Cerebral Vasospasm in Extracranial Carotid Artery Stenting
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To evaluate fasudil hydrochloride for the prevention of cerebral vasospasm (CVS) in extra-cranial carotid angioplasty and stenting (CAS). We retrospectively analyzed 178 patients with unilateral CAS who were given intravenous fasudil hydrochloride during the perioperative period. CVS, hypotension, stroke, and mortality incidence rates were recorded. Of the cohort studied, 80.9 % patients exhibited no local CVS, asymptomatic vasospasm was observed in 17.4 % patients and symptomatic vasospasm in 1.7 % patients via DSA imaging. All CVS was relieved and symptoms disappeared after intra-arterial infusion of papaverine hydrochloride. Intracerebral hemorrhage occurred in two cases during the perioperative period, one of which resulted in death. CVS is a severe complication of CAS. Fasudil hydrochloride can rapidly relieve cerebral vasospasm, has no selective effect on cerebral vasculature, and little influence on blood pressure. It is suitable for the prevention of CVS during interventional treatment of ischemic cerebrovascular disease.
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- Clinical Investigation of Fasudil for the Prevention of Cerebral Vasospasm in Extracranial Carotid Artery Stenting
Cell Biochemistry and Biophysics
Volume 68, Issue 1 , pp 185-188
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Cerebral vasospasm
- Fasudil hydrochloride
- Carotid artery
- Industry Sectors
- Author Affiliations
- 1. Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China
- 2. Department of Neurology, The First Affiliated Hospital of General Hospital of PLA, Beijing, China
- 3. Institute of Neuroscience, Chongqing Medical University, Chongqing, China