Cell Biochemistry and Biophysics

, Volume 67, Issue 1, pp 207–213

Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea

  • Jianling Sun
  • Guolan Gao
  • YuLian Gao
  • liJuan Xiong
  • Xiaoying Li
  • Jihong Guo
  • Yueming Zhang
Translational Biomedical Research

DOI: 10.1007/s12013-013-9535-6

Cite this article as:
Sun, J., Gao, G., Gao, Y. et al. Cell Biochem Biophys (2013) 67: 207. doi:10.1007/s12013-013-9535-6

Abstract

Crataegus sanguinea is a wild plant, which has been widely grown in the north and south of the Tianshan mountains in Xinjiang. In order to explore their anti-cancer properties, edible wild plants from Xinjiang have been tested for their antitumor properties. We used Ames tests, mouse bone marrow polychromatic erythrocytes micronucleus tests, and tumor cells cultured in vitro to study the anti-mutagenic and anti-tumor effects of C. sanguinea extract. We have shown that C. sanguinea has anti-mutagenic effect, but no mutagenicity. Cell culture in vitro experiments show that there is no inhibition of growth or increase in cell death on normal mouse fibroblasts, but a stronger inhibition of cell growth and an increase in cell death of Hep-2 and MGC-803 tumor cells. The results of this study illustrate that C. sanguinea extract has both anti-mutagenic and anti-tumor effects.

Keywords

Crataegus sanguineaTumor cellAnti-mutagenicAntitumor

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jianling Sun
    • 1
  • Guolan Gao
    • 2
  • YuLian Gao
    • 2
  • liJuan Xiong
    • 2
  • Xiaoying Li
    • 3
  • Jihong Guo
    • 4
  • Yueming Zhang
    • 5
  1. 1.Department of CardiologyAviation General HospitalBeijingChina
  2. 2.Department of Gynecological and OncologyAviation General HospitalBeijingChina
  3. 3.Department of Geriatric CardiologyChinese PLA General HospitalBeijingChina
  4. 4.Electrophysiology Group, Department of CardiologyPeople’s Hospital, Peking UniversityBeijingChina
  5. 5.Department of Nutrition and Food HygieneXinJiang Medical UniversityUrumqiChina