Cell Biochemistry and Biophysics

, Volume 65, Issue 2, pp 97–105

The Structure, Function, and Regulation of Mycobacterium FtsZ

Review Paper

DOI: 10.1007/s12013-012-9415-5

Cite this article as:
Hong, W., Deng, W. & Xie, J. Cell Biochem Biophys (2013) 65: 97. doi:10.1007/s12013-012-9415-5


FtsZ is a widely distributed major cytoskeletal protein involved in the archaea and bacteria cell division. It is the most critical component in the division machinery and similar to tubulin in structure and function. Four major roles of FtsZ have been characterized: cell elongation, GTPase, cell division, and bacterial cytoskeleton. FtsZ subunits can be assembled into protofilaments. Mycobacteria consist of a large family of medical and environmental important bacteria, such as M. leprae, M. tuberculosis, the pathogen of leprosy, and tuberculosis. Structure, function, and regulation of mycobacteria FtsZ are summarized here, together with the implication of FtsZ as potential novel drug target for anti-tuberculosis therapeutics.


MycobacteriumFtsZStructureFunctionRegulation moleculesRegulation mechanismPotential anti-TB drug target



Filamentous temperature-sensitive mutant Z


Inner membrane protein A binds directly to Z-ring


Filamentous temperature-sensitive mutant A


Z-ring-associated protein


Septum development protein


Induction of the cell division inhibitor A


Negative regulator of FtsZ ring formation protein A


Minicell locus protein C and D

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life SciencesSouthwest UniversityChongqingChina