Translational Biomedical Research

Cell Biochemistry and Biophysics

, Volume 62, Issue 2, pp 403-406

First online:

Effect of Retreatment on the End-stage Sudden Deafness

  • Zhai SuoqiangAffiliated withHospital of Otorhinolaryngology Head & Neck Surgery, Institute of Otorhinolaryngology Head & Neck Surgery, Chinese PLA General Hospital Email author 
  • , Yu NingAffiliated withHospital of Otorhinolaryngology Head & Neck Surgery, Institute of Otorhinolaryngology Head & Neck Surgery, Chinese PLA General Hospital
  • , Zheng GuiliangAffiliated withHospital of Otorhinolaryngology Head & Neck Surgery, Institute of Otorhinolaryngology Head & Neck Surgery, Chinese PLA General Hospital
  • , Zhu YuhuaAffiliated withHospital of Otorhinolaryngology Head & Neck Surgery, Institute of Otorhinolaryngology Head & Neck Surgery, Chinese PLA General Hospital
  • , Qin HeAffiliated withHospital of Otorhinolaryngology Head & Neck Surgery, Institute of Otorhinolaryngology Head & Neck Surgery, Chinese PLA General Hospital

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Abstract

Microcirculatory disturbance of inner ear is probably one of the important etiological factors of sudden deafness. The purpose of this study was to evaluate the effect of retreatment on the end-stage sudden deafness. For this purpose, the patients who met with the criteria for sudden deafness and showed poor response to conventional therapy over 2 months were assigned randomly to the retreatment group. Pure tone audiometry was conducted before and after retreatment among the 103 patients (112 ears). Sodium bicarbonate and dexamethasone were injected by intravenous drip for 2 days and batroxobin 5BU for 6 days. Data were analyzed using analysis of variance and t test to determine the efficacy of retreatment. These data show that the efficacy rate in retreatment group was 46.43% and the difference between before and after retreatment was significant (P < 0.01). It was, therefore, concluded that retreatment of the end-stage sudden deafness could improve the audition of the patients and should be valuable in clinics. In this regard, the combination of sodium bicarbonate and dexamethasone proved a rational therapeutic regimen for the end-stage sudden deafness. However, further large-size multicenter studies will be required for independent validation of these findings.

Keywords

Sudden deafness Retreatment Sodium bicarbonate Dexamethasone Batroxobin