Cell Biochemistry and Biophysics

, Volume 61, Issue 1, pp 1–22

Fluid Dynamics of Heart Development

Review Paper

DOI: 10.1007/s12013-011-9158-8

Cite this article as:
Santhanakrishnan, A. & Miller, L.A. Cell Biochem Biophys (2011) 61: 1. doi:10.1007/s12013-011-9158-8

Abstract

The morphology, muscle mechanics, fluid dynamics, conduction properties, and molecular biology of the developing embryonic heart have received much attention in recent years due to the importance of both fluid and elastic forces in shaping the heart as well as the striking relationship between the heart’s evolution and development. Although few studies have directly addressed the connection between fluid dynamics and heart development, a number of studies suggest that fluids may play a key role in morphogenic signaling. For example, fluid shear stress may trigger biochemical cascades within the endothelial cells of the developing heart that regulate chamber and valve morphogenesis. Myocardial activity generates forces on the intracardiac blood, creating pressure gradients across the cardiac wall. These pressures may also serve as epigenetic signals. In this article, the fluid dynamics of the early stages of heart development is reviewed. The relevant work in cardiac morphology, muscle mechanics, regulatory networks, and electrophysiology is also reviewed in the context of intracardial fluid dynamics.

Keywords

Heart developmentHemodynamicsShear stressMathematical modelingFluid dynamics

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringGeorgia Institute of TechnologyAtlantaUSA
  2. 2.Department of MathematicsThe University of North Carolina at Chapel HillChapel HillUSA