Cardiovascular Toxicology

, Volume 7, Issue 2, pp 160–164

Novel antioxidants in anthracycline cardiotoxicity

Article

DOI: 10.1007/s12012-007-0019-z

Cite this article as:
Hideg, K. & Kálai, T. Cardiovasc Toxicol (2007) 7: 160. doi:10.1007/s12012-007-0019-z

Abstract

It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.

Keywords

Anthracyclines Antioxidants Cardiomyopathy EPR Free radicals Nitroxides 

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  1. 1.Department of Organic and Medicinal ChemistryUniversity of PécsPecsHungary

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