Novel antioxidants in anthracycline cardiotoxicity
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- Hideg, K. & Kálai, T. Cardiovasc Toxicol (2007) 7: 160. doi:10.1007/s12012-007-0019-z
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It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.