Biological Trace Element Research

, Volume 152, Issue 3, pp 327–332

Serum Trace Elements Levels in Preeclampsia and Eclampsia: Correlation with the Pregnancy Disorder


  • Touhida Ahsan
    • Department of Gynaecology and ObstetricsIbn Sina Medical College
  • Salina Banu
    • Institute of Nutrition and Food ScienceUniversity of Dhaka
  • Quamrun Nahar
    • Department of Biochemistry and Cell Biology, Biomedical Research Group, BIRDEM
  • Monira Ahsan
    • Department of Pharmaceutical Chemistry, Faculty of PharmacyUniversity of Dhaka
  • Md. Nazrul Islam Khan
    • Institute of Nutrition and Food ScienceUniversity of Dhaka
    • Institute of Nutrition and Food ScienceUniversity of Dhaka

DOI: 10.1007/s12011-013-9637-4

Cite this article as:
Ahsan, T., Banu, S., Nahar, Q. et al. Biol Trace Elem Res (2013) 152: 327. doi:10.1007/s12011-013-9637-4


Preeclampsia and eclampsia are fatal medical complications of pregnancy accounting for 20–80 % of increased maternal death in developing countries. Their aetiologies are still under investigation. Serum trace elements have been suggested to be involved in the pathogenesis of preeclampsia. Aim of this study was to address the correlation of serum trace elements with preeclampsia and eclampsia. It was a comparative cross-sectional study conducted on conveniently recruited 44 preeclampsia, 33 eclampsia and 27 normotensive pregnant patients. Atomic absorption spectrometry was employed to analyse serum concentrations of Ca, Mg, Cu, Zn and Fe. Data were analysed by Student's t test, one-way analysis of variance and multinomial logistic and binary regression analyses. p < 0.05 was considered as a level of significance. In preeclampsia, the serum Ca and Mg were significantly lower than those in eclampsia, while Cu and Zn values were higher. Significant changes of Ca, Mg and Cu were noted among preeclampsia, eclampsia and pregnant control. Serum Ca and Mg indicated a positive association, and Cu gave a negative association in preeclampsia. Cu/Fe ratio was high in eclampsia. Significant correlations of Mg with Zn in eclampsia and Mg with Fe in preeclampsia and eclampsia were predicted. Significant changes in serum trace element levels were present in preeclampsia and eclampsia that may have a link with the pathogenesis of pregnancy disorder.


Trace elementsCorrelationAssociationPreeclampsiaEclampsia

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© Springer Science+Business Media New York 2013