Biological Trace Element Research

, Volume 152, Issue 3, pp 310–315

Impaired Heart Rate Recovery in Patients with Endemic Fluorosis

  • M. Koray Adali
  • Ercan Varol
  • Fatih Aksoy
  • Atilla Icli
  • I. Hakki Ersoy
  • Mehmet Ozaydin
  • Dogan Erdogan
  • Abdullah Dogan
Article

DOI: 10.1007/s12011-013-9627-6

Cite this article as:
Adali, M.K., Varol, E., Aksoy, F. et al. Biol Trace Elem Res (2013) 152: 310. doi:10.1007/s12011-013-9627-6

Abstract

The objective of the present study was to determine the heart rate recovery index (HRRI), a marker of autonomic nervous system function in patients with endemic fluorosis. Forty patients with endemic fluorosis (16 men/24 women) and 40 age-, sex-, and body mass index-matched healthy controls (16 men/24 women) with normal fluoride intake were enrolled in this study. HRRI was calculated by subtracting the heart rate values at the first, second, and third minutes of the recovery phase from the peak heart rate (HRRI 1, HRRI 2, HRRI 3). Urine fluoride levels of fluorosis patients were significantly (P < 0.001) higher than control subjects as expected. HRRI 2 was significantly lower in fluorosis patients than in the controls. The incidence of abnormal HRRI 1 was significantly higher in fluorosis patients than in the controls (P < 0.05). We observed that HRRI, a marker of autonomic nervous system function, is impaired in patients with chronic fluorosis.

Keywords

Endemic fluorosisHeart rate recovery indexAutonomic nervous system

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • M. Koray Adali
    • 1
  • Ercan Varol
    • 1
  • Fatih Aksoy
    • 1
  • Atilla Icli
    • 2
  • I. Hakki Ersoy
    • 3
  • Mehmet Ozaydin
    • 1
  • Dogan Erdogan
    • 1
  • Abdullah Dogan
    • 1
  1. 1.Department of Cardiology, Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey
  2. 2.Department of CardiologyKirsehir State HospitalIspartaTurkey
  3. 3.Department of EndocrinologyIsparta State HospitalIspartaTurkey