Biological Trace Element Research

, Volume 151, Issue 1, pp 85–91

Ferulic Acid Modulates Fluoride-Induced Oxidative Hepatotoxicity in Male Wistar Rats

Authors

    • Department of Biotechnology, School of Biotechnology and Health SciencesKarunya University
  • Kavitha Subbiah
    • Department of Biotechnology, School of Biotechnology and Health SciencesKarunya University
  • Angelin Arumugam
    • Department of Biotechnology, School of Biotechnology and Health SciencesKarunya University
  • J. Giftson Senapathy
    • Department of Biotechnology, School of Biotechnology and Health SciencesKarunya University
Article

DOI: 10.1007/s12011-012-9534-2

Cite this article as:
Panneerselvam, L., Subbiah, K., Arumugam, A. et al. Biol Trace Elem Res (2013) 151: 85. doi:10.1007/s12011-012-9534-2

Abstract

The present study is aimed to evaluate the protective effect of ferulic acid (FA) on fluoride-induced oxidative hepatotoxicity in male Wistar rats. Fluoride (25 mg/L) was given orally to induce hepatotoxicity for 12 weeks. Hepatic damage were assessed using status of pathophysiological markers like serum marker enzymes like aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, gamma glutamyl transferase, lactate dehydrogenase, bilirubin, lipid profile, total protein content levels, and histopathological studies. Treatment with FA significantly reduced the degree of histological abberations and rescued lipid peroxidation, as observed from reduced levels of lipid hydroperoxides, nitric oxide, restored levels of enzymic and non-enzymic antioxidants, and total protein content, with a concomitant decline in the levels of marker enzymes and lipid profile in fluoride-induced rats. These results suggest that ferulic acid has the ability to protect fluoride-induced hepatic damage.

Keywords

Fluoride Ferulic acid Oxidative stress Hepatotoxicity

Abbreviations

FA

Ferulic acid

ROS

Reactive oxygen species

SOD

Superoxide dismutase

CAT

Catalase

GSH

Reduced glutathione

GPx

Gultathione peroxidase

TBARS

Thiobarbituric acid reactive substances

LOOH

Lipid hydroperoxides

Vitamin C

Ascorbic acid

NO

Nitric oxide

AST

Aspartate transaminase

ALT

Alanine transaminase

LDH

Lactate dehydrogenase

GGT

Gamma glutamyl transferase

ALP

Alkaline phosphatase

ACP

Acid phosphatase

TG

Triglycerides

LDL-C

Low-density lipoprotein

HDL-C

High-density lipoprotein

VLDL-C

Very low-density lipoprotein

DMRT

Ducan’s multiple range test

Copyright information

© Springer Science+Business Media New York 2012