Biological Trace Element Research

, Volume 146, Issue 2, pp 224-229

Buffalo (Bubalus bubalis) Epiphyseal Proteins Counteract Arsenic-Induced Oxidative Stress in Brain, Heart, and Liver of Female Rats

  • Vijay K. BhartiAffiliated withNeurophysiology Laboratory Division of Physiology & Climatology, Indian Veterinary Research InstituteNutrition and Toxicology Laboratory, Defence Institute of High Altitude Research (DIHAR), Defence Research and Development Organization (DRDO), Ministry of Defence Email author 
  • , R. S. SrivastavaAffiliated withNeurophysiology Laboratory Division of Physiology & Climatology, Indian Veterinary Research Institute
  • , B. SharmaAffiliated withProtein Chemistry Laboratory Division of Biochemistry and Food Science, Indian Veterinary Research Institute
  • , J. K. MalikAffiliated withDivision of Pharmacology and Toxicology, Indian Veterinary Research Institute

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Arsenic (As) toxicity through induction of oxidative stress is a well-known mechanism of organ toxicity. To address this problem, buffalo epiphyseal proteins (BEP, at 100 μg/kg BW, i.p. for 28 days) were administered intraperitoneally to female Wistar rats exposed to As (100 ppm sodium arsenite via drinking water for 28 days). Arsenic exposure resulted in marked elevation in lipid peroxidation in brain, cardiac, and hepatic tissues, whereas significant (p < 0.05) adverse change in catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, and reduced glutathione level were observed in cardiac, hepatic, and brain tissues of As-administered animals. BEP significantly (p < 0.05) counteracted all the adverse changes in antioxidant defense system brought about by As administration. Based on these results, we consider BEP as a potent antioxidant to be used for protection from arsenic-induced oxidative stress related damage of vital organs.


Arsenic Buffalo epiphyseal proteins Brain Heart Liver Oxidative stress