Biological Trace Element Research

, Volume 145, Issue 3, pp 369–374

Protective Effects of Curcumin against Sodium Fluoride-Induced Toxicity in Rat Kidneys

  • Seyed Fazel Nabavi
  • Akbar Hajizadeh Moghaddam
  • Shahram Eslami
  • Seyed Mohammad Nabavi
Article

DOI: 10.1007/s12011-011-9194-7

Cite this article as:
Nabavi, S.F., Moghaddam, A.H., Eslami, S. et al. Biol Trace Elem Res (2012) 145: 369. doi:10.1007/s12011-011-9194-7

Abstract

In the present study, the protective effect of curcumin against sodium fluoride-induced nephrotoxicity was evaluated in rats. Renal injury was induced by daily administration of 600 ppm sodium fluoride in drinking water for 1 week. One week before the administration of fluoride, the animals selected as study group were given curcumin (10 and 20 mg/kg body weight, intraperitoneally). After 1 week, lipid peroxidation level, activities of superoxide dismutase, catalase, and level of glutathione in kidney homogenate were measured. Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant. The results show that curcumin and vitamin C treatment prior to fluoride administration normalized the levels of serum creatinine, serum urea, and blood urea nitrogen. Moreover, curcumin and vitamin C administrations prevented the antioxidant enzyme decreasing and lipid peroxidation levels imbalance. In conclusion, curcumin treatment at the doses of 10 and 20 mg/kg (intraperitoneally) showed significant nephroprotective effects.

Keywords

Oxidative stress Creatinine Serum urea SOD 

Abbreviations

GSH

Reduced glutathione

NaF

Sodium fluoride

TCA

Trichloro acetic acid

TBA

Thiobarbituric acid

BSA

Bovine serum albumin

BUN

Blood urea nitrogen

Cr

Creatinine

CAT

Catalase

SOD

Superoxide dismutase

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Seyed Fazel Nabavi
    • 1
  • Akbar Hajizadeh Moghaddam
    • 2
  • Shahram Eslami
    • 3
  • Seyed Mohammad Nabavi
    • 1
    • 2
  1. 1.National Elites Foundation of IranTehranIran
  2. 2.Department of BiologyUniversity of MazandaranBabolsarIran
  3. 3.Mazandaran University of Medical SciencesSariIran

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